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β-Nicotinamide adenine dinucleotide phosphate monosodium salt

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β-NADP? Monosodium Salt CAS 1184-16-3 Full English Technical Datasheet

CAS No.: 1184-16-3
Full Name: β-Nicotinamide Adenine Dinucleotide Phosphate, Oxidized Form, Monosodium Salt
Abbreviation: β-NADP?·Na / NADP Monosodium / TPN? Monosodium
Synonyms: Coenzyme II monosodium salt, Triphosphopyridine nucleotide monosodium salt, NADP Sodium Salt
IUPAC Name: sodium 1-[(2R,3R,4S,5R)-5-({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methyl phosphonato}oxy)(oxido)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1λ?-pyridin-1-ylium
Molecular Formula: C??H??N?NaO??P?
Molecular Weight: 765.40 g/mol (anhydrous)
MDL No.: MFCD00036262
PubChem CID: 87565510

Test Item	Standard Specification
Appearance	White to pale off-white crystalline powder
Odor	Odorless
Solubility	Freely soluble in purified water & neutral PBS buffer; slightly soluble in methanol; insoluble in ethanol, acetone, oils, alkanes
UV Characteristic Absorption	λmax = 260 nm; No absorbance at 340 nm (distinguish from NADPH)
UV Ratio (pH=7.0)	A???/A??? = 0.78–0.88; A???/A??? = 0.16–0.26
pH (1% aqueous solution)	5.2 ~ 6.8
Melting Point	175–178 °C (decompose)
Stability	Stable under cool, dark, sealed environment; less light-sensitive than NADPH; decomposes under high temperature, strong alkali & strong oxidants
Hygroscopicity	Moderately hygroscopic; avoid long-term exposure to air moisture

QC Item	Standard Limit	Test Method
Assay (HPLC, anhydrous basis)	≥98.0%; Premium ≥99.0%	RP-HPLC UV 260 nm
Loss on Drying (KF)	≤0.70%	Karl Fischer Titration
Reduced NADPH Impurity	≤1.00%	HPLC UV 340 nm
Single Unknown Related Impurity	≤0.30%	HPLC
Total Related Impurities	≤1.00%	HPLC
Enzymatic Activity Verification	Pass G6PDH substrate activity test	UV Spectrophotometry

Microbe Index	Standard
Total Aerobic Microbial Count	≤500 CFU/g
Yeast & Mold	≤50 CFU/g
Pathogens (E.coli, Salmonella, S. aureus)	Negative per 25g

Oxidized Form of Coenzyme II (NADP?)

The primary electron acceptor in pentose phosphate pathway; captures hydride to generate NADPH, the core reducing power for all anabolic metabolism.
Universal Dehydrogenase Cofactor

Indispensable co-substrate for glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase, cytochrome P450 monooxygenases, steroid reductases.
Antioxidant System Precursor

Continuous supply of NADPH to regenerate reduced glutathione (GSH), eliminating intracellular ROS and alleviating oxidative stress.
Gold Standard Substrate for Clinical IVD Kits

Core raw material for enzymatic cycling detection kits for G6PD deficiency screening, blood lipid, liver function, antioxidant biomarkers.
Biocatalysis Redox Cofactor

Applied in industrial biocatalytic reduction reactions for chiral alcohol, steroid and pharmaceutical intermediate synthesis.

G6PD deficiency neonatal screening kits, serum glutathione reductase assay, triglyceride & cholesterol enzymatic detection
Formula Tip: Prepare working buffer at pH 7.0–8.0 to maximize stability

Pentose phosphate pathway, redox metabolism, enzyme kinetics research
Cell culture medium additive, biosensor raw material, high-throughput enzymatic screening

Chiral compound bioreduction, cytochrome P450 drug metabolism simulation, anti-oxidation new drug cell experiments

Used as starting coenzyme to study cellular anti-aging & mitochondrial protection mechanisms

Mild irritant to skin, eyes and respiratory tract upon direct inhalation or contact
Not for oral administration or direct cosmetic addition
No cytotoxicity under standard in-vitro biochemical working concentration
Lab operation requires nitrile gloves, safety goggles and dust mask