1. Core Product Specifications

Product Name: Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt
Abbreviation: NADP+ Disodium Salt, Oxidized Coenzyme II Disodium Salt
CAS No.: 24292-60-2
Molecular Formula: C??H??N?Na?O??P?
Molecular Weight: 789.35
Appearance: White to off-white crystalline powder, odorless, highly hygroscopic, non-caking with ultra-low impurity content
Purity: ≥99.0% (Tested by HPLC)
Moisture Content: ≤3.0%
Heavy Metals: ≤10ppm
Endotoxin: ≤0.1EU/mg
Residue on Ignition: ≤0.1%
Solubility: Freely soluble in pure water and physiological buffers with fast dissolution and stable clear solution; slightly soluble in ethanol, insoluble in organic solvents
Storage Conditions: Store sealed at 2-8℃ in dry and dark environment; strictly avoid moisture, air exposure and oxidative decomposition
Production Technology: Enzymatic catalytic synthesis, directional disodium salt modification, multi-stage chromatographic purification, low-temperature vacuum freeze-drying technology
Product Form: Stable oxidized NADP+ disodium salt active structure, high-stability modified form of Coenzyme II
Shelf Life: 24 months under standard low-temperature sealed and dry storage conditions

2. Professional Product Introduction

Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt (CAS: 24292-60-2) is a highly stable disodium salt modified form of oxidized Coenzyme II. As the core secondary coenzyme in organisms after NAD+, it serves as an exclusive key cofactor for the pentose phosphate pathway, lipid synthesis and glutathione circulation. Unlike NAD+ which mainly participates in catabolic energy metabolism, NADP+ focuses on anabolic metabolism and antioxidant defense systems, dominating cellular reducing power supply, fatty acid and cholesterol synthesis, vitamin metabolism, and immune antioxidant stress response. Natural free NADP+ features poor stability and is prone to hydrolysis and deactivation. Through directional disodium salt coordination modification, this product greatly optimizes molecular structural stability and water solubility while completely retaining the full biological activity of oxidized Coenzyme II. It efficiently provides cells with reducing capacity, maintains cellular redox homeostasis and enhances antioxidant defense. Widely applied in enzymatic research, biochemical kit development, cellular metabolism mechanism experiments, biomedical intermediates and high-end antioxidant functional raw materials, it is an indispensable core coenzyme material for scientific research and commercial functional formulation.

3. Product Description

This product is high-purity oxidized NADP+ disodium salt crystalline powder, refined by advanced enzymatic catalytic synthesis and precise disodium salt formation technology. Invalid impurities and isomers are thoroughly removed via multi-stage high-precision chromatographic purification, delivering stable purity above 99.0%, uniform batch quality and consistent activity. Adopting low-temperature vacuum freeze-drying technology to fully lock complete coenzyme biological activity, it effectively solves the inherent defects of natural NADP+ such as high hygroscopicity, easy hydrolysis, room-temperature deactivation and poor aqueous stability. All key indicators including heavy metals, endotoxin and residual solvents strictly meet international high-end scientific research, biomedical and biochemical reagent standards. Featuring excellent water solubility, the powder dissolves rapidly to form clear and long-term stable aqueous solution, compatible with precision biochemical reaction systems, enzyme activity detection systems and cell culture systems. As a directly active oxidized Coenzyme II finished material, it requires no secondary in-vivo conversion and directly participates in the pentose phosphate pathway, antioxidant redox circulation and lipid synthesis pathways. It achieves higher bioavailability and efficacy stability than ordinary free NADP+, suitable for long-term storage, cross-border transportation, precision scientific experiments and large-scale commercial production.

4. Core Product Advantages

1. Disodium Salt Modification with Greatly Improved Stability
Adopting dual sodium ion coordinated stable structure, the compact molecular framework effectively resists hydrolysis, oxidation and temperature fluctuation. It completely solves the defects of natural NADP+ including moisture-induced deterioration, short aqueous solution half-life and easy activity attenuation, maintaining stable activity throughout storage, transportation, experimentation and formulation with excellent batch repeatability.

2. Exclusive Coenzyme II Activity with Unique Metabolic Functions
Different from NAD+ that focuses on energy catabolism, NADP+ specializes in cellular anabolism and antioxidant reduction. It efficiently empowers the glutathione antioxidant system, promotes lipid synthesis and regulates immune oxidative stress, covering unique physiological pathways that cannot be replaced by Coenzyme I, ensuring irreplaceable application value in scientific research and formulation development.

3. Ultra-High Purity & Reagent-Grade Strict Quality
Manufactured by enzymatic synthesis and multi-stage precision purification, the product reaches ≥99% high purity with strictly controlled impurities, heavy metals and endotoxin. Free of harmful chemical residues, it meets high standards for biochemical reagents and cell culture, supporting high-precision enzyme activity tests, kit development and biomedical research.

4. Excellent Water Solubility & High System Compatibility
Sodium salt modification significantly enhances hydrophilicity, achieving fast dissolution and stable clear solution with a wide pH tolerance range. It is fully compatible with various buffer solutions, biochemical reaction systems, cell culture media and water-based functional formulas without precipitations or antagonism, requiring no additional solubilizers for convenient formulation.

5. Dual Applicability for Scientific Research & Commercial Use
It is widely applicable for professional scientific research including pentose phosphate pathway research, oxidative stress analysis, enzyme kinetics and metabolomics studies. Meanwhile, it supports mass production of high-end antioxidant raw materials, biochemical reagents and pharmaceutical intermediates. With mature production technology and stable supply, complete COA, MSDS and other compliance documents are available to support global cross-border trade and customized production.