1. Core Product Specifications

Product Name: NADPH Tetrasodium Salt
Full Name: Reduced Nicotinamide Adenine Dinucleotide Phosphate Tetrasodium Salt
Abbreviation: NADPH, β-NADPH
CAS No.: 2646-71-1
Product Type: Natural cellular reduced coenzyme, biological redox electron donor, core enzymatic cofactor, biochemical research reagent, metabolic pathway substrate, key antioxidant system component
Molecular Formula: C??H??N?Na?O??P?
Molecular Weight: 833.35 g/mol
Appearance: White to off-white crystalline powder, uniform loose texture, non-caking, odorless with ultra-low impurities
Purity: ≥99.0% (HPLC, Research Grade / Biochemical Grade)
Moisture Content: ≤2.0%
Heavy Metals: ≤10ppm
Residue on Ignition: ≤0.1%
Solubility: Freely soluble in pure water, PBS buffer and various aqueous reaction systems, forming clear and stable solutions without precipitation; insoluble in common organic solvents
Transport Condition: Sealed, dry, light-proof and low-temperature transportation to avoid reductive activity inactivation caused by high temperature and vibration
Storage Condition: Long-term dry powder storage at -20℃ in sealed, dry and dark environment; short-term storage at 2–8℃. Strictly avoid light exposure, oxidation and repeated freeze-thaw cycles. Reduced coenzyme is highly susceptible to oxidative degradation under strong light and high temperature, requiring strictly controlled storage conditions
Production Technology: Biological fermentation purification, enzymatic reduction modification, stable tetrasodium salt formation technology, multi-stage high-precision HPLC refining, low-temperature vacuum freeze-drying activity locking technology
Core Bioactivity: Provides cellular reducing equivalents, participates in anabolic reactions, resists oxidative stress, scavenges reactive oxygen species, maintains intracellular redox homeostasis, supports dehydrogenase/reductase enzymatic reactions, mediates lipid and nucleic acid anabolism
Shelf Life: 24 months for sealed dry powder stored at -20℃ under standard dry and dark conditions
Usage Restriction: For scientific research, biochemical enzymology experiments, cellular redox mechanism and metabolic pathway research only. Strictly prohibited for unauthorized clinical application, food addition and illegal use

2. Professional Product Introduction

NADPH Tetrasodium Salt (CAS: 2646-71-1) is a core natural reduced coenzyme and electron donor in organisms, serving as an indispensable key cofactor for cellular anabolism and antioxidant defense systems. Corresponding to oxidized NADP+, NADPH exists in a high-energy reduced state and widely participates in multiple anabolic pathways including fatty acid synthesis, cholesterol synthesis and nucleic acid synthesis. As the primary source of cellular reducing power, it efficiently eliminates ROS free radicals, relieves oxidative stress damage and maintains dynamic cellular redox balance. In enzymatic reactions mediated by various dehydrogenases and reductases, NADPH specifically provides protons and electrons, acting as the standard core co-substrate for reduction reactions. As a stable tetrasodium salt form, it exhibits higher water solubility, superior physicochemical stability and stronger degradation resistance compared with free-state NADPH. It is widely applicable to in vitro enzymology reactions, cellular metabolic intervention and antioxidant mechanism verification, and serves as a fundamental core reagent for metabolic biology, synthetic biology and antioxidant research.

3. Product Description

This product is high-purity research/biochemical-grade NADPH tetrasodium salt crystalline powder, fully compliant with the official standard molecular structure of CAS 2646-71-1. Produced via mature biological purification and stable salt-forming technology, it features pure reduced configuration without oxidized NADP+ residues, miscellaneous salt impurities or structural defects. Multi-stage high-precision preparative HPLC thoroughly removes fermentation residues, protein impurities, inorganic by-products and oxidative degradation fragments, ensuring stable HPLC purity above 99.0% with highly unified batch reduction activity and excellent experimental repeatability. The tetrasodium salt modification significantly enhances water solubility and storage stability, effectively solving the instability defects of natural NADPH such as easy oxidation and activity loss, and maintains stable coenzyme activity in conventional experimental systems. With strictly controlled heavy metals, ash content, moisture and residual impurities, the product possesses ultra-low cytotoxicity and excellent biocompatibility. It is fully suitable for in vitro enzyme kinetic experiments, cellular oxidative stress models, animal and plant metabolomics research, antioxidant pathway verification and synthetic biology enzyme system construction, meeting the stringent quality standards of high-end biochemical scientific research and precision enzymology experiments.

4. Core Product Advantages

1. Pure Reduced Activity Without Oxidative Impurity Interference
Retains complete NADPH reduced configuration with negligible NADP+ oxidation residues, ensuring pure and specific coenzyme activity. It eliminates experimental data deviation caused by oxidized impurities and guarantees accurate and controllable redox and enzymatic reaction results.

2. Stable Tetrasodium Salt Modification for Long-Term Experiments
Exclusive tetrasodium salt structure greatly improves water solubility and physicochemical stability, delivering superior hydrolysis and oxidation resistance compared with ordinary free NADPH, ensuring longer storage life and stable experimental performance.

3. Universal Core Reductive Coenzyme with Wide Applicability
As a universal biological electron donor, it covers comprehensive research fields including anabolism, antioxidant defense, enzymatic catalysis and redox homeostasis, serving as an essential basic reagent for metabolic biology, enzyme engineering and antioxidant mechanism research.

4. Endogenous Homologous Structure with Excellent Biocompatibility
Fully consistent with natural intracellular NADPH structure without exogenous toxic modification. It causes no specific interference to cells, enzyme systems and microorganisms, adapting to various in vivo and in vitro biochemical experimental systems with high reliability.

5. High Purity & Strict Quality Control with Superior Batch Stability
HPLC purity ≥99.0% with strictly controlled impurity indicators and highly unified batch activity, solubility and stability. It fully supports high-precision enzyme kinetic tests, parallel control experiments and long-term scientific research projects.