β-NADPH TETRA(CYCLOHEXYLAMMONIUM) SALT
- Model：1G,10G,1KG,5KG,25KG
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage |
FOR R&D RESEARCH USE
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| deliveryInfo |
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| appearance |
white to off white powder
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| aliasen |
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| supplyCapacity |
500000KG/Year
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| harbor |
SHENZHEN
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| minorder |
1g
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β-NADPH Tetra(cyclohexylammonium) Salt CAS 100929-71-3 Full English Technical Datasheet
1. Basic Chemical Information
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CAS No.: 100929-71-3
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Full Name: β-Nicotinamide Adenine Dinucleotide Phosphate Reduced Tetra(cyclohexylammonium) Salt
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Abbreviation: NADPH·4CyHexNH?, NADPH Cy4N, TPNH Tetracyclohexanamine Salt
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Synonyms: NADPH cyclohexyl ammonium salt, Reduced Coenzyme II Tetracyclohexylamine Salt
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IUPAC Name: Tetracyclohexanamine [(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ({[(2R,3S,4S)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-2,3,4-trihydroxypentyl]phosphonato}oxy)phosphoric acid
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Molecular Formula: C??H??N?O??P? · 4C?H??N / C??H??N??O??P?
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Molecular Weight: 1142.12 g/mol
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MDL No.: MFCD00036264
NADPH Cy4N Chemical Structure
2. Physical & Chemical Properties
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Test Item
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Standard Specification
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Appearance
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White to pale yellow crystalline powder
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Odor
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Slight cyclohexylamine odor; odorless after full vacuum sealing
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Solubility
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Soluble in DMSO, DMF, methanol; sparingly soluble in neutral water; soluble in alkaline aqueous buffer; insoluble in alkane, ester, vegetable oil
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UV Characteristic Absorption
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λmax = 260 nm & 340 nm; Molar extinction coefficient ε??? = 6220 (pH 8.0–10.0)
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A??? / A??? Ratio
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2.20 ~ 2.45
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Stability
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Highly light-sensitive; decomposes rapidly under acid, high temperature and UV irradiation; stable under dark, alkaline, low-temperature vacuum storage
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Hygroscopicity
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Moderately hygroscopic; avoid long-term exposure to air
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pH (saturated DMSO solution)
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8.5 ~ 10.0
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3. Quality Specifications (Biochemical Research Grade)
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QC Item
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Standard Limit
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Test Method
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Assay (HPLC, anhydrous basis)
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≥98.0%; Premium ≥99.0%
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RP-HPLC UV 340 nm
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Loss on Drying (KF)
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≤6.0%
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Karl Fischer Titration
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Oxidized Impurity NADP?
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≤1.80%
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HPLC
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Single Unknown Related Impurity
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≤0.30%
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HPLC
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Total Related Impurities
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≤1.00%
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HPLC
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Enzymatic Activity Validation
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Pass glutathione reductase activity test
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UV Spectrophotometry
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Heavy Metals
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Heavy Metal
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Limit
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Lead (Pb)
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≤0.5 ppm
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Arsenic (As)
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≤1.0 ppm
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Cadmium (Cd)
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≤0.1 ppm
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Mercury (Hg)
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≤0.1 ppm
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Microbial Limits
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Microbe Index
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Standard
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Total Aerobic Microbial Count
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≤500 CFU/g
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Yeast & Mold
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≤50 CFU/g
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Pathogens (E.coli, Salmonella, S.aureus)
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Negative per 25g
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4. Core Biochemical Mechanism & Advantages
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Lipophilic Modified NADPH Cofactor
Compared with sodium salt NADPH (CAS 2646-71-1) and free acid NADPH (CAS 53-57-6), tetra(cyclohexylammonium) salt improves lipid solubility, compatible with organic solvent reaction systems for cell membrane penetration experiments.
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Universal Biological Reducing Equivalent Carrier
Supplies hydride ions for anabolic pathways: lipid, cholesterol, steroid, nucleic acid and amino acid biosynthesis; core substrate for cytochrome P450 metabolic simulation.
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Intracellular Antioxidant Defense Core
Regenerates reduced glutathione (GSH), eliminates ROS free radicals, inhibits lipid peroxidation and oxidative cellular damage.
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Gold Standard Enzymatic Assay Marker
340 nm absorbance signal is the standard detection readout for dehydrogenases, reductases, NOS, G6PDH and clinical diagnostic kits.
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Organic-Soluble Coenzyme for Cell & Organoid Research
Good solubility in DMSO cell culture medium, widely used for intracellular redox intervention experiments.
5. Application Fields & Operation Tips
5.1 Biochemical Laboratory Research
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Enzyme kinetics, pentose phosphate pathway, redox metabolism research
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Cell culture additive, organoid redox intervention, cytochrome P450 metabolic simulation
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High-throughput enzymatic screening with DMSO stock solution preparation
5.2 Clinical Diagnostic Reagent Raw Material
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G6PD deficiency detection kits, glutathione reductase assay, liver antioxidant index detection
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Formula Tip: Prepare working buffer at pH 8.0–10.0 to maximize stability
5.3 Pharmaceutical R&D Intermediate
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Anti-oxidation, mitochondrial protective new drug cell experimental raw material
5.4 Biosensor Raw Material
Redox biosensor cofactor for biomarker quantitative detection
6. Safety Profile
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Irritant to skin, eyes and respiratory tract (GHS hazard Xi); avoid direct inhalation and skin contact
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Contains cyclohexylamine counterion; not suitable for cosmetic or oral formulation
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No cytotoxicity under standard in-vitro biochemical working concentration
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Lab operation requires nitrile gloves, goggles and dust mask
7. Storage & Packaging
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Storage Condition: Hermetic aluminum foil vacuum sealed; long-term storage at -20°C, strictly light-proof & moisture-proof; avoid repeated freeze-thaw cycles; short-term storage ≤4°C
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Shelf Life: 24 months under intact original vacuum packaging
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Packaging: 10mg/50mg/100mg/1g aluminum vacuum foil bags for lab research; 5g/10g foil drums for reagent factory bulk orders
