Thio-Nicotinamide Adenine Dinucleotide
- Model：1G,10G,1KG,5KG,25KG
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage |
FOR R&D RESEARCH USE
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| deliveryInfo |
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| appearance |
white to off white powder
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| aliasen |
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| supplyCapacity |
5000000KG/Year
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| harbor |
SHENZHEN
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| minorder |
10G
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Thio-NAD (Thionicotinamide Adenine Dinucleotide) CAS 4090-29-3 Full English Technical Datasheet
Thio-NAD Chemical Structure
1. Basic Chemical Information
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CAS No.: 4090-29-3
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Full Name: Thionicotinamide Adenine Dinucleotide (Oxidized Form)
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Abbreviation: Thio-NAD / S-NAD / Thionicotinamide-DPN
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Molecular Weight: 679.49 g/mol
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EINECS: 223-828-6
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MDL No.: MFCD00079609
2. Physical & Chemical Properties
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Test Item
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Standard Specification
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Appearance
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Pale yellow to light orange crystalline powder
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Odor
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Odorless
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Solubility
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Freely soluble in water, PBS buffer (pH7.2); slightly soluble in methanol; insoluble in acetone, chloroform, oils
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UV Characteristic Absorption
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Oxidized Thio-NAD: 260 nm; Reduced Thio-NADH: 404 nm (unique detection wavelength vs NADH 340 nm)
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pH (0.5% Aqueous Solution)
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5.0 ~ 6.8
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Hygroscopicity
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Highly hygroscopic, strictly sealed storage required
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Stability
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Light-sensitive, unstable at room temperature long-term storage; stable under -20°C dark vacuum environment; degrade under strong alkali & high temperature
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3. Quality Specifications (Biochemical Research Grade)
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QC Item
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Standard Limit
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Test Method
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Assay (HPLC)
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≥98.0% (Premium ≥99.0%)
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RP-HPLC UV 260 nm
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Loss on Drying
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≤0.80%
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Karl Fischer Titration
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Single Related Impurity
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≤0.30%
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HPLC
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Total Related Impurities
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≤1.00%
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HPLC
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Enzymatic Activity Test
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Pass dehydrogenase activity verification
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Spectrophotometry
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Heavy Metals
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Heavy Metal
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Limit
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Lead (Pb)
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≤0.5 ppm
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Arsenic (As)
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≤1.0 ppm
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Cadmium (Cd)
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≤0.1 ppm
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Mercury (Hg)
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≤0.1 ppm
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Microbial Limits
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Microbe Index
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Standard
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Total Aerobic Microbial Count
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≤100 CFU/g
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Yeast & Mold
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≤10 CFU/g
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Pathogens (E.coli, Salmonella, S.aureus)
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Negative
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4. Core Biochemical Mechanism & Advantages
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Modified NAD+ Coenzyme Substrate
Structural analog of natural NAD?; nicotinamide amide group replaced by thioamide group, retains complete dehydrogenase binding activity.
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Unique Spectroscopic Detection Advantage
Reduced product Thio-NADH has maximum absorbance at 404 nm, far away from endogenous serum protein interference at 340 nm; achieves ultra-high sensitivity enzymatic cycling assay.
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High-Sensitivity Enzymatic Cycling Amplification
Widely used for trace quantification of metabolites, enzymes, proteins in clinical biochemistry; signal amplification efficiency much higher than standard NAD system.
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Redox Electron Transfer Cofactor
Participates in in vitro simulation of mitochondrial energy metabolism electron transport chain, cell redox pathway research.
