1. Core Product Specifications

Product Name: Nicotinic Acid Riboside
Abbreviation: NaNR
Alias: 3-Carboxypyridine Riboside, Nicotinic Acid Nucleoside
CAS No.: 17720-18-2
Product Type: NAD+ biosynthesis precursor, nicotinic acid nucleoside compound, cellular metabolism regulator, biochemical enzymatic reaction substrate, metabolic pathway research reagent
Molecular Formula: C??H??NO?
Molecular Weight: 271.22 g/mol
Chemical Structure: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate inner salt
Appearance: White to off-white crystalline powder, uniform and loose texture, non-caking, odorless with ultra-low impurities
Purity: ≥99.0% (HPLC, Research Grade / Biochemical Grade)
Moisture Content: ≤2.0%
Heavy Metals: ≤10ppm
Residue on Ignition: ≤0.1%
Solubility: Freely soluble in pure water and aqueous buffer solutions, slightly soluble in polar organic solvents. The solution is clear, stable and precipitation-free
Transport Condition: Sealed, dry and light-proof low-temperature transportation, compliant with nucleoside active material storage and transportation standards
Storage Condition: Long-term dry powder storage at -20℃ in sealed, dry and dark environment; short-term storage at 2–8℃. Avoid high temperature, humidity and strong light to prevent nucleoside structural hydrolysis, degradation and activity attenuation
Production Technology: Biological enzymatic catalytic synthesis, precise stereoscopic configuration purification, multi-stage high-precision HPLC refining, low-temperature vacuum drying activity locking technology
Core Bioactivity: Participates in NAD+ de novo and salvage synthesis pathways, regulates cellular energy metabolism, maintains intracellular redox homeostasis, mediates nicotinic acid nucleoside metabolic circulation, and supports synthetic biology mechanism research
Shelf Life: 24 months for sealed dry powder stored at -20℃ under standard dry and dark conditions
Usage Restriction: For scientific research, biochemical enzymology experiments and cellular metabolic pathway research only. Strictly prohibited for unauthorized clinical application, food addition and illegal use

2. Professional Product Introduction

Nicotinic Acid Riboside (NRa, CAS: 17720-18-2) is a natural nicotinic acid-type NAD+ nucleoside precursor and an essential upstream substrate for NAD+ de novo and salvage synthesis pathways. It is completely different from similar metabolic substances such as Nicotinamide Riboside (NR), Nicotinic Acid Mononucleotide (NaMN) and Nicotinamide Mononucleotide (NMN). NRa directly enters the cellular metabolic cycle, generates NaMN through stepwise phosphorylation reactions, and is finally converted into endogenous NAD+, efficiently regulating cellular energy metabolism and redox balance. Featuring stable nucleoside structure, strong pathway specificity and no miscellaneous pathway interference, NRa serves as a core exclusive tool reagent for studying nicotinic acid metabolic branch pathways, nucleoside transformation mechanisms and microbial NAD+ synthesis regulation. With stable biochemical activity, excellent water solubility and superior biocompatibility, it is widely applied in high-end scientific research scenarios including metabolic biology, synthetic biology, enzymology mechanism verification and cellular anti-aging metabolism research.

3. Product Description

This product is high-purity research/biochemical-grade Nicotinic Acid Riboside (NRa) crystalline powder, produced by mature biological enzymatic catalytic synthesis technology. It features accurate and pure stereoscopic configuration, fully consistent with the official standard molecular structure of CAS 17720-18-2, without configurational isomers, synthetic by-product residues or exogenous contamination. Multi-stage preparative HPLC deep refining thoroughly removes trace impurities, incomplete structures and invalid intermediates, ensuring stable HPLC purity above 99.0% with excellent batch consistency and experimental repeatability. As an upstream nucleoside precursor, NRa possesses a single metabolic pathway and specifically initiates the nicotinic acid-type NAD+ synthesis pathway without cross-interference with nicotinamide metabolic pathways, achieving highly controllable experimental variables. With strictly controlled heavy metals, ash content, moisture and residual impurities, the product has ultra-low cytotoxicity and excellent biocompatibility. It is fully suitable for in vitro cellular metabolic intervention experiments, microbial metabolism regulation, nucleoside phosphorylase mechanism research and differential verification of NAD+ pathways, meeting the dual stringent standards of high-end biochemical scientific research and reagent mass production.

4. Core Product Advantages

1. Exclusive NRa Structure with Extreme Pathway Specificity
Strictly conforms to the CAS 17720-18-2 standard nicotinic acid riboside structure, completely differentiated from NR, NaMN and NMN. No cross-contaminating impurities ensure precise targeting of the nicotinic acid metabolic pathway and eliminate experimental confusion and data deviation.

2. Upstream Core NAD+ Precursor for Complete Metabolic Research
As the uppermost nucleoside substrate in the NAD+ synthesis cascade, it completely restores the endogenous nicotinic acid metabolic cycle and supports both de novo and salvage pathway research, filling the research gap at the nucleoside level and broadening experimental applicability.

3. Stable Structure and High Experimental Repeatability
The nucleoside molecular configuration exhibits excellent hydrolysis and degradation resistance. It maintains stable activity under conventional low-temperature storage and retains high solution stability, supporting long-term cellular intervention and continuous batch control experiments with reliable and consistent data output.

4. Green Enzymatic Synthesis with High Biosafety
Adopts eco-friendly biological enzymatic synthesis without harmful solvent residues or toxic by-products. Its mild physicochemical properties minimize non-specific interference, making it suitable for multiple living experimental systems including cell and microbial cultures.

5. Ultra-High Purity for High-End Precision Research
HPLC purity ≥99.0% with strictly controlled impurity indicators and highly unified batch quality. It fully meets the high-precision research requirements of differential metabolic pathway analysis, enzyme kinetic experiments and synthetic biology modification studies.