Professional Product Parameters: CAS 910463-68-2 (Semaglutide)

1. Basic Identification

• CAS No.：910463-68-2
• Product Name：Semaglutide
• IUPAC Name：L-Histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N?-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine
• Peptide Sequence：H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
• Synonyms：NN9535; Ozempic; Rybelsus; Semaglutide acetate; Semaglutidum
• MDL：MFCD28026336

2. Chemical Data

• Molecular Formula：C???H???N??O??
• Molecular Weight：4113.58 g/mol (exact mass: 4113.09 Da)
• Elemental Analysis：C 54.64%, H 7.12%, N 15.32%, O 22.92%
• Calculated LogP：-1.87
• TPSA：1432.70 ?2
• Hydrogen Bond Donors：48
• Hydrogen Bond Acceptors：67
• Rotatable Bonds：142

3. Physical & Chemical Properties

• Appearance：White to off?white amorphous powder
• Solubility：
  • Water：Slightly soluble (≈0.3 mg/mL)
  • DMSO：Soluble (≈5 mg/mL)
  • 20% ACN：Soluble (≈50 mg/mL)
  • Insoluble in hexane, ether, chloroform
• Melting Point：>190 °C (decomposition)
• pH (1% aqueous solution)：7.0–9.0
• Stability：Hygroscopic; sensitive to light, heat, and oxidation; aqueous solutions unstable, prepare fresh daily
• Storage：-20 °C (long?term, 24 months); 2–8 °C (short?term, 2 weeks); sealed, dry, light?proof, inert gas protection

4. Product Specifications (Typical)

• Purity：≥98.0% (HPLC); ≥99.0% (Pharmaceutical API grade)
• Single Maximum Impurity：≤1.0%
• Peptide Content：≥80.0%
• Acetate Content：5.0%–12.0%
• Moisture：≤8.0%
• Heavy Metals：Total ≤10 ppm; Pb ≤0.5 ppm, Cd ≤2.5 ppm, Hg ≤1.5 ppm, As ≤0.15 ppm
• Residue on Ignition：≤1.0%
• Endotoxin：≤5 EU/mg
• Specific Rotation：-15.0° to -10.0° (c=10 mg/mL, H?O, anhydrous)
• Grade：Research grade / Pharmaceutical API grade
• Packing：1 mg, 5 mg, 10 mg, 25 mg, 100 mg, 1 g (lyophilized, aluminum foil bag); bulk packaging

5. Biological Function & Applications

• Mechanism：Long?acting GLP?1 receptor agonist (EC?? = 6.2 pM); contains Aib (2?aminoisobutyric acid) and fatty acid side chain for albumin binding; plasma half?life ≈7 days
• Core Bioactivity：
  • Glucose?dependent insulin secretion promotion
  • Glucagon secretion inhibition
  • Gastric emptying delay and appetite reduction
  • β?cell function preservation and weight management

6. Safety & Handling Instructions

• GHS Classification：Not classified as hazardous; reproductive toxicity (Category 2)
• Handling：Avoid inhalation, skin and eye contact; use in fume hood; wear PPE (gloves, goggles)
• Disposal：Dispose per local chemical waste regulations
• Note：For laboratory research and pharmaceutical development only; unauthorized human administration is prohibited