Professional Product Parameters: CAS 204656-20-2 (Liraglutide)

1. Basic Identification

• CAS No.：204656-20-2
• Product Name：Liraglutide 
• IUPAC Name：L-Histidyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-[N?-(1-oxohexadecyl)-L-α-glutamyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine
• Peptide Sequence：HAEGTFTSDVSSYLEGQAAK(γ-Glu-palmitoyl)EFIAWLVRGRG
• Synonyms：NN2211; Victoza; Saxenda; Liraglutidum; Liraglutide acetate
• MDL Number：MFCD16217357

2. Chemical Data

• Molecular Formula：C???H???N??O??
• Molecular Weight：3751.20 g/mol
• Exact Mass：3750.92 Da
• Calculated LogP：-2.12
• TPSA：1312.50 ?2
• Hydrogen Bond Donors：45
• Hydrogen Bond Acceptors：62
• Rotatable Bonds：128

3. Physical & Chemical Properties

• Appearance：White to off?white amorphous solid powder
• Solubility：
  • Water：Slightly soluble (≈0.5 mg/mL)
  • DMSO：Slightly soluble (≈2 mg/mL)
  • 0.1 M NaOH：Soluble (≈10 mg/mL)
  • Insoluble in hexane, ether, chloroform
• Melting Point：>182 °C (decomposes)
• pH (1% aqueous solution)：5.0–7.0
• Stability：Hygroscopic; sensitive to light, heat, and oxidation; aqueous solutions unstable, prepare fresh before use
• Storage Condition：Long?term storage at -20 °C; short?term at 2–8 °C; sealed, dry, light?proof, inert gas protection

4. Product Specifications (Typical)

• Purity：≥98.0% (HPLC); ≥99.0% (Pharmaceutical API grade)
• Single Maximum Impurity：≤1.0%
• Peptide Content：≥80.0%
• Acetate Content：5.0%–12.0%
• Moisture：≤10.0%
• Heavy Metals：Total ≤10 ppm; Pb ≤0.5 ppm, Cd ≤2.5 ppm, Hg ≤1.5 ppm, As ≤0.15 ppm
• Residue on Ignition：≤1.0%
• Endotoxin：≤5 EU/mg
• Grade：Research grade / Pharmaceutical API grade
• Packing：1 mg, 5 mg, 10 mg, 25 mg, 100 mg, 1 g (lyophilized, aluminum foil bag); bulk packaging

5. Biological Function & Applications

• Mechanism：Long?acting GLP?1 receptor agonist (EC?? = 61 pM); 97% sequence homology to human GLP?1(7?37); resistant to DPP?4 degradation; plasma half?life ≈13 hours
• Core Bioactivity：
  • Enhances glucose?dependent insulin secretion from pancreatic β?cells
  • Suppresses glucagon release from α?cells
  • Delays gastric emptying and reduces appetite, promoting weight loss
  • Improves β?cell function and insulin sensitivity
• Applications：
  • Pharmaceutical API (brand names: Victoza® for type 2 diabetes; Saxenda® for obesity)
  • Research tool for diabetes, obesity, metabolic syndrome, and cardiovascular protection studies
  • Intermediate for long?acting peptide drug development

6. Safety & Handling Instructions

• GHS Hazard Classification：Not classified as hazardous; reproductive toxicity (Category 2)
• Handling：Avoid inhalation, skin and eye contact; operate in well?ventilated area with PPE (gloves, goggles)
• Waste Disposal：Dispose in accordance with local chemical waste regulations
• Note：For laboratory research and pharmaceutical development only; unauthorized human administration is prohibited