Product
|
Dihexa
- Brand：NO
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：1401708-83-5
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 509000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Dihexa (PNB-0408 / Cognitive Peptide) CAS 1401708-83-5 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 1401708-83-4
- Full Name: N-Hexanoyl-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide
- Short Name: Dihexa, PNB-0408, Cognitive Dipeptide
- Synonyms: Hexanoyl-Tyr-Ile-Ahx-NH?, Angiotensin IV mimetic neuroprotective peptide, Brain booster peptide
- IUPAC Name: N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide
- Molecular Formula: C??H??N?O?
- Molecular Weight: 504.66 g/mol
- MDL No.: MFCD18382564
- Core Feature: Synthetic angiotensin IV analog; high oral bioavailability, crosses blood-brain barrier; potent HGF/c-Met agonist for neurogenesis, only for neuroscience & cognitive health research/supplement raw material, not mainstream cosmetic raw material
Dihexa powde
Dihexa crystal powder
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White fine lyophilized crystalline powder |
| Odor | Odorless |
| Solubility | Soluble in DMSO, ethanol, methanol; slightly soluble in glycerin; nearly insoluble in pure water, mineral oil, acetone; requires organic carrier for aqueous formulation |
| pH (0.1% ethanol dispersion) | 4.0 ~ 6.0 |
| Thermal Operation Rule | Add below 40℃ during formulation; avoid sustained heating over 55℃ |
| Stability | Stable under vacuum, dark, weak acid/neutral storage; incompatible with strong alkali, high-concentration oxidants, long-term UV irradiation; tyrosine residue prone to photo-oxidation |
| Hygroscopicity | Slightly hygroscopic, nitrogen-filled vacuum packaging required |
3. Quality Specifications (Research / Supplement Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm / 275 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Hexanoic Acid Residue | ≤0.10% | HPLC |
Heavy Metals
Lead (Pb) ≤0.5 ppm; Arsenic (As) ≤1.0 ppm; Cadmium (Cd) ≤0.1 ppm; Mercury (Hg) ≤0.1 ppm
Microbial Limits
Total Aerobic Microbial Count ≤500 CFU/g; Yeast & Mold ≤50 CFU/g; E. coli, Salmonella, S. aureus Negative per 25g
4. Core Biological Mechanism & Efficacy
-
Potent HGF/c-Met Pathway Agonist (Core Neuroprotective Mechanism)
Binds and stabilizes hepatocyte growth factor (HGF), enhances HGF activation of c-Met receptor; blocks heparanase-mediated HGF degradation, far more potent than endogenous BDNF for synaptic growth.
-
Boost Neurogenesis & Synaptogenesis
Promotes formation of new neural synaptic connections, improves synaptic plasticity, repairs damaged neuronal circuits; reverses cognitive decline in Alzheimer’s disease preclinical models.
-
Anti-Neuroinflammation & Reduce Neuronal Apoptosis
Suppresses microglia overactivation, lowers pro-inflammatory cytokine levels in brain tissue, reduces ROS oxidative stress and neuronal cell death caused by aging and neurodegeneration.
-
Improve Spatial Memory & Learning Ability
Enhances memory consolidation, relieves brain fog, fatigue and age-related cognitive impairment; supports long-term brain vitality.
-
Peripheral Anti-Aging Auxiliary Effect
Elevates peripheral HGF levels to protect vascular endothelial cells, improve microcirculation, relieve systemic oxidative aging.
5. Application Fields & Recommended Dosage
5.1 Nootropic Oral Supplements (Main Application)
Cognitive support capsules, memory enhancement powder, anti-brain fog longevity nutritional formulations
- Standard daily oral dosage: 10–100 mg/day
5.2 Neuroscientific Laboratory Research
Alzheimer’s disease mechanism study, synaptic plasticity assay, neurotrophic pathway cell culture substrate
- Typical cell culture working concentration: 1 pM – 10 nM
5.3 High-End Anti-Aging Compound Formulations
Longevity complex powder, systemic anti-inflammaging oral nutrient
- Recommended addition: 50–300 mg per daily serving
Formula Operation Tips
Optimal pH range: 4.0–6.0; compatible with NR, NAD+ precursors, ginkgo extract, omega-3; dissolve in ethanol/glycerin first before mixing with water phase; add UV stabilizer to protect tyrosine.
6. Safety Profile
- Low acute oral toxicity; well tolerated in animal preclinical trials
- No neurotoxicity, no cytotoxicity to neurons at routine supplement/research concentrations
- Rare mild gastrointestinal discomfort only at ultra-high oral doses
- Not approved as mainstream cosmetic raw material; avoid direct leave-on skin use due to poor water solubility
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, cool dry light-proof warehouse; short-term storage ≤4°C; avoid repeated opening & freeze-thaw cycles
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg nitrogen-filled aluminum vacuum foil bags for supplement factories & research labs; 25kg double PE inner bag + paper drum for bulk orders
