Product
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Kisspeptin-10
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：374675-21-5
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 50000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Kisspeptin-10 (Metastin 45–54) CAS 374675-21-5 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 374675-21-5
- Full Name: Human Kisspeptin-10, Metastin (45–54) Amide
- Abbreviation: Kp-10
- Peptide Sequence: H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH? (YNWNSFGLRF-NH?)
- Synonyms: GPR54 agonist peptide, Vasoconstrictive decapeptide, Anti-angiogenesis research peptide
- Molecular Formula: C??H??N??O??
- Molecular Weight: 1302.44 g/mol
- MDL No.: MFCD18382241
- Core Feature: Endogenous GPR54/KISS1R receptor agonist; research-grade decapeptide, not approved for cosmetic leave-on skincare
Kisspeptin-10 Molecular Structure
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White lyophilized fine crystalline powder |
| Odor | Odorless |
| Solubility | Freely soluble in purified water & PBS buffer (25 mg/mL); highly soluble in DMSO (100 mg/mL); insoluble in ethanol, mineral oil, acetone |
| pH (0.1% aqueous solution) | 5.0 ~ 7.0 |
| Thermal Stability | Avoid sustained heating above 50℃; prepare stock solutions at room temperature or below 40℃ |
| Stability | Stable under neutral/weak acidic aqueous systems; sensitive to strong alkali, high-concentration oxidants and long-term UV irradiation; tryptophan residue prone to photo-oxidation |
| Hygroscopicity | Moderately hygroscopic, vacuum nitrogen-sealed storage mandatory |
3. Quality Specifications (Biomedical Research Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm / 280 nm |
| Loss on Drying (KF) | ≤0.60% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.20% | HPLC |
| Free Amino Acid Residues | ≤0.10% | HPLC |
| Endotoxin | ＜10 EU/mg | LAL Test (low endotoxin for cell assays) |
Heavy Metals
Lead (Pb) ≤0.5 ppm; Arsenic (As) ≤1.0 ppm; Cadmium (Cd) ≤0.1 ppm; Mercury (Hg) ≤0.1 ppm
Microbial Limits
Total Aerobic Microbial Count ≤100 CFU/g; Yeast & Mold ≤10 CFU/g; E. coli, Salmonella, S. aureus Negative per 25g
4. Core Biological Mechanism & Research Efficacy
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High-Affinity GPR54/KISS1R Receptor Agonist (Core Function)
Decapeptide fragment of metastin/kisspeptin protein; selectively binds to GPR54 receptor on multiple cell types, triggers intracellular calcium mobilization and downstream signal cascades.
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Vasoconstriction & Anti-Angiogenesis
Induces vasoconstriction of microvascular endothelial cells; inhibits endothelial cell migration, proliferation and new blood vessel formation, widely used for tumor metastasis and vascular biology research.
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Reproductive Endocrinology Research Tool
Regulates GnRH secretion in hypothalamus; key substrate for puberty onset, gonadotropin release and reproductive hormone pathway in neuroendocrine studies.
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Anti-Tumor Metastasis Research Marker
Suppresses tumor cell invasion and distant metastasis by blocking angiogenesis and matrix metalloproteinase activation; standard positive control for cancer metastasis in vitro assays.
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Bone Metabolism Modulation
Activates NFATc4/BMP2 signaling to promote osteoblast differentiation, applied in bone remodeling and osteoporosis mechanism research.
5. Application Fields & Recommended Working Concentration
5.1 Basic Biomedical Research (Exclusive Use)
- Reproductive endocrinology cell culture, GnRH secretion pathway study
- Tumor metastasis & anti-angiogenesis in vitro cell assays
- Osteoblast differentiation, bone metabolism research
- Metabolomics & GPR54 receptor ligand mass spectrometry tracing
- Typical cell culture working concentration: 10 nM – 1 μM
5.2 Pharmaceutical Drug Development Research
Redox pathway drug screening, anti-metastasis small molecule cofactor screening, neuroendocrine protective compound evaluation
Important Restriction
Not an approved cosmetic raw material; prohibited for leave-on skincare, hair care or body topical formulations.
6. Safety Profile
- Laboratory research reagent only; not for human oral injection, skin application or clinical therapy
- Mild irritant to eyes and respiratory tract upon direct inhalation of powder
- No cytotoxicity at standard cell assay concentrations; high micromolar doses may induce mild cell stress
- Lab operation requirements: nitrile gloves, safety goggles, fume hood for powder weighing
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, strictly light-proof, oxygen-proof & moisture-proof; avoid repeated opening and freeze-thaw cycles; short-term storage ≤4°C
- Shelf Life: 24 months under intact original vacuum packaging
- Packaging: 5mg/100mg/1g nitrogen-filled aluminum foil bags for academic labs & pharmaceutical R&D institutes
