Product
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Palmitoyl Pentapeptide-4
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：214047-00-4
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 500000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Palmitoyl Pentapeptide-4 (Matrixyl Original, Pal-KTTKS) CAS 214047-00-4
1. Basic Chemical Information
- CAS No.: 214047-00-4
- INCI Name: Palmitoyl Pentapeptide-4
- Trade Name: Matrixyl, Pal-KTTKS
- Peptide Sequence: Palmitoyl-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS)
- IUPAC Name: (2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid
- Synonyms: Matrixyl base peptide, collagen-stimulating lipopentapeptide, anti-wrinkle pentapeptide
- Molecular Formula: C??H??N?O??
- Molecular Weight: 802.05 g/mol
- MDL No.: MFCD32689740
- Core Feature: Original matrikine signal peptide, palmitoyl lipophilic chain enhances skin penetration, classic single-component anti-aging peptide
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White fine crystalline powder |
| Odor | Odorless |
| Solubility | Soluble in ethanol, glycerin, DMSO; dispersible in water with solubilizer; compatible with oil-in-water & water-in-oil emulsions due to palmitoyl lipophilic tail |
| pH (0.1% ethanol-water dispersion) | 3.5 ~ 6.0 |
| Thermal Operation Rule | Add below 40℃ during emulsification; avoid sustained heating over 60℃ |
| Stability | Stable under weak acid & neutral cosmetic systems; incompatible with strong alkali, high-concentration oxidants, long-term UV irradiation |
| Hygroscopicity | Slightly hygroscopic; vacuum nitrogen-sealed storage required |
3. Quality Specifications (Cosmetic Premium Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Palmitic Acid Residue | ≤0.10% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
Lead (Pb) ≤0.5 ppm; Arsenic (As) ≤1.0 ppm; Cadmium (Cd) ≤0.1 ppm; Mercury (Hg) ≤0.1 ppm
Microbial Limits
Total Aerobic Microbial Count ≤500 CFU/g; Yeast & Mold ≤50 CFU/g; E. coli, Salmonella, S. aureus Negative per 25g
4. Core Biological Mechanism & Efficacy
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Matrikine Signal Peptide to Massively Stimulate Collagen Synthesis
Biomimetic fragment of type I collagen; penetrates dermis via palmitoyl lipophilic chain, activates fibroblast proliferation, significantly upregulates Type I/III/IV collagen, fibronectin and hyaluronic acid secretion, thickens dermal layer, lifts sagging skin and smooths static wrinkles.
-
Inhibit MMP Degradation Enzymes
Suppresses matrix metalloproteinase (MMP) activity to slow collagen breakdown caused by UV radiation and natural aging, delay wrinkle deepening and skin loosening.
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Anti-Inflammaging & Antioxidation
Scavenges epidermal ROS free radicals, reduces chronic low-grade inflammatory damage, improves dull, rough and uneven mature skin texture.
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Repair Damaged Skin Barrier
Promotes regular arrangement of dermal extracellular matrix fibers, reduces transepidermal water loss, relieves dry and sensitive skin.
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Multi-Peptide Synergistic Compatibility
Combined with Palmitoyl Tetrapeptide-7 (Pal-GQPR) to form Matrixyl 3000, realizing dual effects of collagen regeneration + anti-inflammation; also compatible with acetyl hexapeptide-8, copper peptide for multi-effect anti-aging formulas.
5. Application Fields & Recommended Dosage
5.1 Anti-Aging Facial Skincare (Core Application)
Matrixyl anti-wrinkle serum, firming lifting cream, mature skin repair lotion, anti-photoaging essence
- Recommended addition: 0.001% ~ 0.05% (w/w)
5.2 Eye Contour Care
Anti-sagging eye cream, static wrinkle repair gel, dark circle firming essence
- Recommended addition: 0.001% ~ 0.08% (w/w)
5.3 Post-Sun & Sensitive Skin Repair
UV damage recovery soothing lotion, barrier repair nourishing cream
- Recommended addition: 0.001% ~ 0.03% (w/w)
Formula Operation Tips
Optimal pH range: 4.0–6.5; compatible with hyaluronic acid, panthenol, vitamin C derivatives, GHK-Cu; add at low-temperature late emulsification stage with glycerin/ethanol solubilizer.
6. Safety Profile
- Non-irritating to facial skin and delicate ocular mucosa at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- Excellent biocompatibility with human dermal fibroblasts and keratinocytes
- No cytotoxicity under routine leave-on cosmetic usage concentration
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, cool dry light-proof warehouse; short-term storage ≤4°C; avoid repeated opening & high temperature exposure
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
