Product
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Acetyl Hexapeptide-8
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：616204-22-9
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 50Tons/Year |
| harbor | SHENZHEN |
| minorder | 1g |
Acetyl Hexapeptide-8 (Argireline) CAS 616204-22-9 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 616204-22-9
- INCI Name: Acetyl Hexapeptide-8
- Trade Name: Argireline, also called Acetyl Hexapeptide-3
- Peptide Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH?
- IUPAC Name: N-Acetyl-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide
- Synonyms: Topical botox peptide, SNAP-25 inhibitory hexapeptide, anti-expression wrinkle peptide
- Molecular Formula: C??H??N??O??S
- Molecular Weight: 888.99 g/mol
- MDL No.: MFCD32689454
- Core Feature: Biomimetic fragment of SNAP-25 protein, classic neurotransmitter inhibition anti-wrinkle peptide
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white lyophilized crystalline powder |
| Odor | Odorless |
| Solubility | Freely soluble in purified water, neutral PBS buffer; soluble in glycerin & DMSO; slightly soluble in ethanol; insoluble in mineral oil, acetone |
| pH (0.1% aqueous solution) | 4.2 ~ 6.8 |
| Thermal Operation Rule | Add below 40℃ during emulsification; avoid sustained heating over 60℃ |
| Stability | Stable under weak acid & neutral cosmetic systems; incompatible with strong alkali, high-concentration oxidants, long-term UV irradiation; methionine residue prone to oxidation under air |
| Hygroscopicity | Moderately hygroscopic, vacuum nitrogen-sealed storage required |
3. Quality Specifications (Cosmetic Premium Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous peptide basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Acetic Acid Residue | ≤0.10% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
Lead (Pb) ≤0.5 ppm; Arsenic (As) ≤1.0 ppm; Cadmium (Cd) ≤0.1 ppm; Mercury (Hg) ≤0.1 ppm
Microbial Limits
Total Aerobic Microbial Count ≤500 CFU/g; Yeast & Mold ≤50 CFU/g; E. coli, Salmonella, S. aureus Negative per 25g
4. Core Biological Mechanism & Efficacy
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Block SNARE Complex Assembly to Reduce Dynamic Wrinkles (Core Mechanism)
Mimics SNAP-25 protein terminal fragment, competitively occupies binding site of SNARE complex, inhibits vesicle fusion and acetylcholine neurotransmitter release, reduces involuntary contraction of facial expression muscles, smooths frown lines, crow’s feet, forehead lines and nasolabial folds.
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Mild "Topical Botox" Effect, Safe for Daily Use
No neurotoxicity compared with injection botulinum toxin; reversible muscle relaxation, retains natural facial expression without stiff numbness.
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Prevent Static Wrinkle Formation
Long-term continuous use reduces repeated muscle traction damage to dermal collagen fibers, stops dynamic expression lines from evolving into permanent deep static wrinkles.
-
Auxiliary Antioxidation & Anti-Inflammation
Scavenges epidermal ROS free radicals, relieves inflammatory stress caused by frequent facial expressions, improves dull, rough mature skin texture.
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Multi-Peptide Synergistic Compatibility
Compound with Palmitoyl Tripeptide-1+Palmitoyl Tetrapeptide-7 (Matrixyl 3000) for dual effects: instant wrinkle smoothing + collagen regeneration & anti-inflammaging.
5. Application Fields & Recommended Dosage
5.1 Anti-Wrinkle Facial Skincare (Main Application)
Anti-expression line serum, anti-frown ampoule, crow’s feet repair cream, firming anti-aging lotion
- Recommended addition: 0.005% ~ 0.10% (w/w)
5.2 Eye Contour Care
Anti-wrinkle eye gel, dynamic line repair eye cream, fatigue relief eye essence
- Recommended addition: 0.005% ~ 0.08% (w/w)
5.3 Mature Skin Compound Anti-Aging Formulas
Overnight repair mask, anti-photoaging nourishing cream
- Recommended addition: 0.001% ~ 0.05% (w/w)
Formula Operation Tips
Optimal pH range: 4.0–6.5; compatible with hyaluronic acid, panthenol, vitamin E derivatives, copper peptide GHK-Cu; add at low-temperature late emulsification stage, match with UV stabilizer to slow oxidation of methionine.
6. Safety Profile
- Non-irritating to facial skin and delicate ocular mucosa at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk for leave-on skincare products
- No cytotoxicity to keratinocytes and dermal fibroblasts under routine usage concentration
- Mild, safe for sensitive mature skin long-term continuous care
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, strictly light-proof, oxygen-proof & moisture-proof; avoid repeated opening and freeze-thaw cycles; short-term storage ≤4°C
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
