Product
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Palmitoyl Tripeptide-1
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：147732-56-7
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 5000000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Palmitoyl Tripeptide-1 (Pal-GHK) CAS 147732-56-7 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 147732-56-7
- INCI Name: Palmitoyl Tripeptide-1
- Abbreviation: Pal-GHK, Palmitoyl-Gly-His-Lys
- Core Compound of Matrixyl 3000 (matched with Palmitoyl Tetrapeptide-7 CAS 221227-05-0)
- Peptide Sequence: Palmitoyl-Glycyl-L-Histidyl-L-Lysine
- IUPAC Name: N2-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine
- Synonyms: Palmitoyl oligopeptide, Lipophilic GHK collagen stimulating peptide
- Molecular Formula: C??H??N?O?
- Molecular Weight: 578.79 g/mol
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MDL No.: MFCD18251733
Pal-GHK Chemical Structure
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white fine crystalline powder |
| Odor | Odorless |
| Solubility | Soluble in DMSO, ethanol, glycerin; dispersible in water with solubilizer; compatible with oil/water emulsions due to palmitoyl lipophilic chain |
| UV Absorption Max | 283 nm |
| pH (0.1% ethanol-water dispersion) | 4.0 ~ 6.5 |
| Thermal Operation Rule | Add below 40℃ during emulsification; avoid sustained heating over 60℃ |
| Stability | Stable under weak acid & neutral cosmetic systems; incompatible with strong alkali, high-concentration oxidants, long-term UV irradiation |
| Hygroscopicity | Slightly hygroscopic; vacuum sealed storage required |
3. Quality Specifications (Cosmetic Premium Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Palmitic Acid Residue | ≤0.10% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
Lead (Pb) ≤0.5 ppm; Arsenic (As) ≤1.0 ppm; Cadmium (Cd) ≤0.1 ppm; Mercury (Hg) ≤0.1 ppm
Microbial Limits
Total Aerobic Microbial Count ≤500 CFU/g; Yeast & Mold ≤50 CFU/g; E. coli, Salmonella, S. aureus Negative per 25g
4. Core Biological Mechanism & Efficacy
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Classic Matrikine Signal Peptide to Boost ECM Synthesis
Lipophilic modified GHK tripeptide; palmitoyl chain enhances skin penetration through stratum corneum to dermis. Activates fibroblast proliferation, significantly upregulates Type I/III collagen, fibronectin and hyaluronic acid secretion, thickens dermal density, lifts sagging skin.
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Synergistic Anti-Aging with Palmitoyl Tetrapeptide-7 (Matrixyl 3000)
Pal-GHK (collagen booster) + Pal-GQPR (anti-inflammatory) compound achieves dual anti-aging effects: promote extracellular matrix + inhibit inflamm-aging, reduces fine lines, looseness and dullness of mature skin.
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Suppress MMP Matrix Degradation Enzymes
Inhibits matrix metalloproteinase activity to slow collagen breakdown caused by UV and aging, delays wrinkle formation.
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Antioxidation & Skin Barrier Repair
Scavenges ROS free radicals, alleviates UV photoaging damage, improves epidermal keratin arrangement, reduces transepidermal water loss for dry sensitive skin.
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Eye Contour Auxiliary Firming Effect
Improves elasticity around eyes, relieves fine lines and mild sagging, widely compounded with Acetyl Tetrapeptide-5 for multi-effect eye care formulas.
5. Application Fields & Recommended Dosage
5.1 Anti-Aging Facial Skincare (Core Application)
Matrixyl anti-wrinkle serum, firming lifting cream, mature skin repair lotion, anti-photoaging essence
- Recommended addition: 0.001% ~ 0.05% (w/w)
5.2 Eye Contour Care
Firming eye cream, anti-wrinkle eye gel, dark circle repair essence
- Recommended addition: 0.001% ~ 0.08% (w/w)
5.3 Post-Sun & Sensitive Skin Repair
UV recovery soothing lotion, barrier repair nourishing cream
- Recommended addition: 0.001% ~ 0.03% (w/w)
Formula Operation Tips
Optimal pH range: 4.0–6.5; compatible with hyaluronic acid, panthenol, vitamin C derivatives, copper peptide GHK-Cu; add at low-temperature late emulsification stage with glycerin/ethanol solubilizer.
6. Safety Profile
- Non-irritating to facial skin and ocular mucosa at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- Excellent biocompatibility with human dermal fibroblasts and keratinocytes
- No cytotoxicity under routine leave-on cosmetic usage concentration
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, cool dry light-proof warehouse; short-term storage ≤4°C; avoid repeated opening & high temperature exposure
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
