Product
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Acetyl Octapeptide-3
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：868844-74-0
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 5000000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Acetyl Octapeptide-3 (SNAP-8) CAS 868844-74-3 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 868844-74-0
- INCI Name: Acetyl Octapeptide-3
- Trade Name: SNAP-8
- Alias: Acetyl Octapeptide-1, Acetyl Glutamyl Octapeptide-3
- Peptide Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH?
- IUPAC Name: N-Acetyl-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-α-aspartamide
- Molecular Formula: C??H??N??O??S
- Molecular Weight: 1075.16 g/mol
- MDL No.: MFCD34179876
- Core Feature: Upgraded SNAP-25 competitive neuropeptide, stronger anti-wrinkle efficacy than Acetyl Hexapeptide-8 (Argireline)
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white lyophilized crystalline powder |
| Odor | Odorless |
| Solubility | Freely soluble in purified water, neutral PBS buffer (pH 6.0–7.5); soluble in glycerin & DMSO; slightly soluble in ethanol; insoluble in mineral oil, acetone |
| pH (0.1% aqueous solution) | 4.2 ~ 6.8 |
| Thermal Operation Rule | Add below 40℃ during emulsification; avoid sustained heating above 60℃ |
| Stability | Stable under weak acid & neutral cosmetic formulas; incompatible with strong alkali, high-concentration oxidants, long-term UV irradiation |
| Hygroscopicity | Moderately hygroscopic, vacuum nitrogen-sealed storage required |
| Sulfur-containing methionine: Avoid long-term exposure to air oxidation |
3. Quality Specifications (Cosmetic Premium Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Acetic Acid Residue | ≤0.10% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
Lead (Pb) ≤0.5 ppm; Arsenic (As) ≤1.0 ppm; Cadmium (Cd) ≤0.1 ppm; Mercury (Hg) ≤0.1 ppm
Microbial Limits
Total Aerobic Microbial Count ≤500 CFU/g; Yeast & Mold ≤50 CFU/g; E. coli, Salmonella, S. aureus Negative per 25g
4. Core Biological Mechanism & Efficacy
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Compete with SNAP-25 to Block SNARE Complex Assembly (Core Anti-Wrinkle)
Biomimetic fragment of SNAP-25 protein; occupies binding site of SNARE complex, inhibits vesicle fusion and acetylcholine neurotransmitter release, reduces excessive contraction of facial expression muscles, smooths dynamic wrinkles (crow’s feet, frown lines, forehead lines).
-
Higher Anti-Wrinkle Activity Than Argireline (Acetyl Hexapeptide-8)
Extended two amino acids based on hexapeptide sequence, stronger binding affinity to SNARE complex, lower effective dosage, longer-lasting muscle relaxation effect.
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Prevent Dynamic Lines Evolving into Permanent Static Wrinkles
Long-term use reduces repeated muscle traction damage to dermal collagen fibers, delays formation of deep static wrinkles and nasolabial folds.
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Mild Antioxidant & Anti-Inflammatory Auxiliary Effect
Scavenges epidermal ROS free radicals, relieves inflammatory stress caused by frequent facial expressions, improves dull and rough mature skin texture.
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Multi-Peptide Synergistic Matching
Compound with Palmitoyl Tripeptide-5 (Syn-Coll) / Palmitoyl Tetrapeptide-7 (Rigin) to realize triple effects: muscle relaxation + collagen regeneration + anti-inflammaging.
5. Application Fields & Recommended Dosage
5.1 Anti-Wrinkle Facial Skincare (Core Application)
Anti-expression line serum, anti-frown ampoule, crow’s feet repair cream, firming anti-aging lotion
- Recommended addition: 0.005% ~ 0.10% (w/w)
5.2 Eye Contour Care
Anti-wrinkle eye gel, lifting eye cream for dynamic eye lines
- Recommended addition: 0.005% ~ 0.08% (w/w)
5.3 Mature Skin Compound Anti-Aging Formulas
Overnight repair mask, anti-photoaging nourishing cream
- Recommended addition: 0.001% ~ 0.05% (w/w)
Formula Operation Tips
Optimal pH range: 4.0–6.5; compatible with hyaluronic acid, panthenol, copper peptide GHK-Cu, vitamin E derivatives; add at low-temperature late emulsification stage, match with UV stabilizer.
6. Safety Profile
- Non-irritating to facial skin and delicate ocular mucosa at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- Reversible mild muscle relaxation, no stiff facial numbness side effects
- No cytotoxicity to keratinocytes and dermal fibroblasts under routine leave-on cosmetic concentration
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, strictly light-proof, oxygen-proof & moisture-proof; avoid repeated opening & freeze-thaw cycles; short-term storage ≤4°C
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
