Product
|
Acetyl Hexapeptide-1
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：448944-47-6
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 5000000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Acetyl Hexapeptide-1 (Melitane / Stellight) CAS 448944-47-6 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 448944-47-6
- INCI Name: Acetyl Hexapeptide-1
- Trade Name: Melitane, Stellight
- Peptide Sequence: Ac-Nle-Ala-His-D-Phe-Arg-Trp-NH?
- IUPAC Name: (2S)-2-acetamido-N-[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]hexanamide
- Synonyms: Melanin-stimulating peptide, tanning peptide, α-MSH biomimetic hexapeptide
- Molecular Formula: C??H??N??O?
- Molecular Weight: 870.01 g/mol
- MDL No.: MFCD32689455
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white lyophilized crystalline powder |
| Odor | Odorless |
| Solubility | Freely soluble in purified water, neutral PBS buffer; soluble in glycerin & DMSO; slightly soluble in ethanol; insoluble in mineral oil, acetone |
| pH (0.1% aqueous solution) | 4.5 ~ 6.8 |
| Thermal Operation Rule | Add below 45℃ during emulsification; avoid sustained heating above 60℃ |
| Stability | Stable under weak acid & neutral cosmetic formulas; incompatible with strong alkali, high-concentration oxidants, long-term UV irradiation |
| Hygroscopicity | Moderately hygroscopic; vacuum nitrogen-sealed storage required |
3. Quality Specifications (Cosmetic Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Acetic Acid Residue | ≤0.10% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
Lead (Pb) ≤0.5 ppm; Arsenic (As) ≤1.0 ppm; Cadmium (Cd) ≤0.1 ppm; Mercury (Hg) ≤0.1 ppm
Microbial Limits
Total Aerobic Microbial Count ≤500 CFU/g; Yeast & Mold ≤50 CFU/g; E. coli, Salmonella, S. aureus Negative per 25g
4. Core Biological Mechanism & Efficacy
-
Biomimetic α-MSH Agonist to Stimulate Melanin Synthesis (Core Function)
Mimics the structure of α-melanocyte-stimulating hormone, selectively binds to melanocyte MC1R receptor, activates intracellular cAMP signal pathway, upregulates tyrosinase activity, accelerates melanin production and uniform deposition in epidermis.
-
Natural Sunless Tanning & Even Skin Bronzing
Achieve uniform natural wheat/bronze skin tone without UV exposure; avoid uneven orange stains caused by dihydroxyacetone (DHA), maintain skin smooth texture.
-
UV Photoprotection & Anti-Photoaging
Endogenous melanin acts as natural UV filter; reduces UV-induced ROS generation, alleviates keratinocyte DNA damage, prevents redness, sunburn and photoaging dullness.
-
Anti-Inflammatory & Barrier Repair Auxiliary Effect
Inhibits UV-triggered inflammatory cytokine release, relieves skin irritation and redness after sun exposure, strengthens epidermal barrier integrity.
-
Hair & Eyebrow Pigment Boost
Promotes melanin generation in hair matrix cells, improves faded gray hair, darkens light-colored eyebrows and eyelashes when added to hair care & lash serums.
5. Application Fields & Recommended Dosage
5.1 Sunless Tanning Skincare (Main Application)
Self-tanning lotion, bronzing serum, gradual tan body cream, UV defense repair emulsion
- Recommended addition: 0.005% ~ 0.10% (w/w)
5.2 Daily UV Protection Skincare
Sunscreen repair essence, anti-photoaging nourishing lotion, outdoor anti-radiation cream
- Recommended addition: 0.001% ~ 0.05% (w/w)
5.3 Hair & Eyelash Care
Gray hair improvement shampoo, dark eyebrow & lash serum
- Recommended addition: 0.001% ~ 0.03% (w/w)
Formula Operation Tips
Optimal pH range: 4.0–6.5; compatible with hyaluronic acid, panthenol, vitamin E derivatives; avoid compounding with high-dose whitening ingredients (nonapeptide-1, tranexamic acid).
6. Safety Profile
- Non-irritating to facial skin, scalp and ocular mucosa at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- No cytotoxicity to melanocytes and keratinocytes, milder than chemical tanning agents
- Safe for long-term continuous use in sun care and tanning series
