Product
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Mu-Conotoxin
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：936616-33-0
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 5000000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
μ-Conotoxin Cn IIIC (Arginine/Lysine Polypeptide, Cononpeptide) CAS 936616-33-0 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 936616-33-0
- Standard Name: μ-Conotoxin Cn IIIC
- INCI Name: Arginine/Lysine Polypeptide
- Trade Names: Cononpeptide, Marine Anti-Wrinkle Conopeptide, CnIII-C
- Synonyms: Mu-Conotoxin, XEP-018, Marine snail muscle relaxation peptide
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Amino Acid Sequence:
Pyr-Glu-Gly-Cys-Cys-Asn-Gly-Pro-Lys-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH?Disulfide bonds: Cys3-Cys10, Cys4-Cys21, Cys15-Cys22
- Molecular Formula: C??H???N??O??S?
- Molecular Weight: 2375.70 g/mol
- EINECS No.: 606-757-9
- MDL No.: MFCD00145036
- Core Feature: Synthetic biomimetic marine cone snail toxin peptide, high-efficiency voltage-gated sodium channel blocker, instant muscle relaxation anti-wrinkle raw material
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White lyophilized crystalline powder |
| Odor | Odorless |
| Solubility | Freely soluble in purified water, PBS buffer (pH 5.0–7.0); soluble in glycerin; slightly soluble in ethanol; insoluble in mineral oil, acetone, ether |
| pH (0.001% aqueous solution) | 5.0 ~ 7.0 |
| Density | 1.71±0.1 g/cm3 |
| Thermal Stability | Add below 40℃ during emulsification; avoid sustained heating above 55℃ |
| Stability | Stable under weak acid & neutral cosmetic systems; incompatible with strong alkali, high-concentration oxidants, long-term UV exposure |
| Hygroscopicity | Moderately hygroscopic, vacuum sealed moisture-proof storage required |
| Disulfide Bond Stability | Susceptible to reducing agents (VC, sulfites) leading to chain breakage and activity loss |
3. Quality Specifications (Cosmetic Premium Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Disulfide Bond Completeness | ≥98% | HPLC / Ellman test |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
| Heavy Metal | Limit |
|---|---|
| Lead (Pb) | ≤0.5 ppm |
| Arsenic (As) | ≤1.0 ppm |
| Cadmium (Cd) | ≤0.1 ppm |
| Mercury (Hg) | ≤0.1 ppm |
Microbial Limits
| Microbe Index | Standard |
|---|---|
| Total Aerobic Microbial Count | ≤500 CFU/g |
| Yeast & Mold | ≤50 CFU/g |
| E. coli, Salmonella, S. aureus | Negative per 25g |
4. Core Biological Mechanism & Efficacy
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Block Skeletal Muscle NaV1.4 Sodium Channel (Instant Wrinkle Smoothing)
Specifically inhibits voltage-gated sodium channel NaV1.4 on facial muscle cells, blocks nerve-muscle electrical signal transmission, reduces involuntary contraction of expression muscles, instantly smooths dynamic wrinkles (crow’s feet, forehead lines, frown lines) without complete muscle paralysis.
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Long-Lasting Anti-Wrinkle & Prevent Static Wrinkle Formation
Continuous use reduces repeated muscle pulling on dermis, slows collagen fiber breakage, prevents dynamic lines from evolving into permanent static wrinkles, longer acting than acetyl hexapeptide-8 (Argireline).
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Mild Anti-Inflammatory & Antioxidant Auxiliary Effect
Scavenges excess ROS in epidermal tissue, relieves inflammatory stress caused by repeated facial expressions, improves rough and dull mature skin texture.
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Compatible with Other Anti-Aging Peptides for Synergistic Effect
Combined with Palmitoyl Tripeptide-5 (Syn-Coll) / Palmitoyl Tetrapeptide-7 (Rigin) to achieve dual effects: instant muscle relaxation + collagen regeneration & anti-inflammaging.
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Sensitive Skin Friendly
Milder neuromodulation mechanism, no stinging or numbness side effects compared with high-dose neuropeptide anti-wrinkle ingredients.
5. Application Fields & Recommended Dosage
5.1 Anti-Wrinkle Facial Skincare (Core Application)
Instant smoothing anti-expression line serum, anti-frown cream, crow’s feet repair essence, firming anti-aging ampoule
- Recommended addition: 0.00005% ~ 0.0025% (0.5–25 ppm, ultra-low effective dosage)
5.2 Eye Contour Care
Anti-wrinkle eye gel, lifting eye cream for dynamic eye lines
- Recommended addition: 0.0001% ~ 0.002% (1–20 ppm)
5.3 Mature Skin Anti-Aging Compound Formulas
Multi-effect anti-aging lotion, overnight repair mask, anti-photoaging nourishing cream
- Recommended addition: 0.00005% ~ 0.001% (0.5–10 ppm)
Formula Operation Tips
Optimal formulation pH range: 4.5–6.5; avoid compounding with high-concentration reducing agents (L-ascorbic acid, sodium sulfite); add at low-temperature late emulsification stage, match with light stabilizer.
6. Safety Profile
- Non-irritating to facial skin and delicate eye mucosa at standard cosmetic ultra-low dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk in leave-on formulations
- No permanent muscle numbness; reversible mild muscle relaxation effect
- No cytotoxicity to keratinocytes and dermal fibroblasts under routine cosmetic concentration
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, strictly light-proof, oxygen-proof & moisture-proof; avoid repeated opening and freeze-thaw cycles; short-term storage ≤4°C
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 100mg/1g/5g aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
