Product
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Palmitoyl Tripeptide-5
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：623172-56-5
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 500000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Palmitoyl Tripeptide-5 (Syn-Coll, Di-TFA Salt) CAS 623172-56-5 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 623172-56-5
- INCI Name: Palmitoyl Tripeptide-5
- Trade Name: Syn-Coll
- Peptide Sequence: Palmitoyl-Lys-Val-Lys (Pal-KVK)
- Full Name: N2-(1-oxohexadecyl)-L-lysyl-L-valyl-L-lysine bis(trifluoroacetate)
- IUPAC Name: (2S)-2-[2-(hexadecanoylamino)-6-aminohexanamido]-3-methylbutanoyl]amino-6-aminohexanoic acid bis(2,2,2-trifluoroacetate)
- Synonyms: Collagen stimulating tripeptide, TGF-β signaling peptide
- Molecular Formula: C??H??N?O? · 2CF?COOH
- Molecular Weight: 839.96 g/mol
- MDL No.: MFCD32089453
Palmitoyl Tripeptide-5 Structure
Structural Formula
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white lyophilized crystalline powder |
| Odor | Slight faint TFA odor, nearly odorless after vacuum sealing |
| Solubility | Soluble in DMSO, DMF, ethanol; sparingly dispersed in neutral water with solubilizer; insoluble in mineral oils, acetone |
| pH (0.1% ethanol-water dispersion) | 3.5 ~ 5.5 |
| Thermal Stability | Add below 40℃ during emulsification; avoid sustained heating above 60℃ |
| Stability | Stable under weak acidic & neutral cosmetic systems; incompatible with strong alkali, high-concentration oxidants, long-term UV exposure |
| Hygroscopicity | Moderately hygroscopic; vacuum sealed moisture-proof storage required |
3. Quality Specifications (Cosmetic Premium Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, peptide base) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Palmitic Acid Residue | ≤0.10% | HPLC |
| Residual Trifluoroacetic Acid | ≤8.0% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
| Heavy Metal | Limit |
|---|---|
| Lead (Pb) | ≤0.5 ppm |
| Arsenic (As) | ≤1.0 ppm |
| Cadmium (Cd) | ≤0.1 ppm |
| Mercury (Hg) | ≤0.1 ppm |
Microbial Limits
| Microbe Index | Standard |
|---|---|
| Total Aerobic Microbial Count | ≤500 CFU/g |
| Yeast & Mold | ≤50 CFU/g |
| E. coli, Salmonella, S. aureus | Negative per 25g |
4. Core Biological Mechanism & Efficacy
-
Mimic Thrombospondin-1 to Activate TGF-β Signaling Pathway
Biomimetic sequence of TSP-1; upregulates endogenous TGF-β release, stimulates fibroblast proliferation to boost extracellular matrix synthesis without exogenous growth factor additionNIKOO Chem....
-
Massively Boost Collagen & Elasticin Production
Significantly increases Type I/II/IV collagen, elastin, hyaluronic acid and fibronectin secretion; thickens dermis, lifts sagging skin, smooths static wrinkles and nasolabial folds.
-
Powerful Antioxidant & Anti-Inflammaging
Scavenges intracellular ROS free radicals, inhibits pro-inflammatory cytokine release, alleviates UV-induced photoaging and chronic low-grade skin inflammation.
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Repair Damaged Skin Barrier & Improve Skin Density
Promotes uniform arrangement of dermal matrix fibers, enhances skin elasticity, fades dullness and rough texture of mature skin.
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Synergistic Anti-Aging Combination
Perfect matching with Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, acetyl hexapeptide-8 for multi-effect firming, anti-wrinkle and anti-aging compound formulas.
5. Application Fields & Recommended Dosage
5.1 Anti-Aging Firming Skincare (Core Application)
Anti-wrinkle serum, lifting firming cream, mature skin repair lotion, anti-photoaging essence
- Recommended addition: 0.001% ~ 0.05% (w/w)
5.2 Eye Contour Care
Anti-sagging eye cream, crow’s feet repair essence, firming eye gel
- Recommended addition: 0.002% ~ 0.08% (w/w)
5.3 Post-Sun & Sensitive Skin Repair
UV damage recovery lotion, barrier repair nourishing cream
- Recommended addition: 0.001% ~ 0.03% (w/w)
Formula Operation Tips
Optimal pH range: 4.0–6.0; compatible with hyaluronic acid, vitamin C derivatives, copper peptide GHK-Cu, panthenol; add at low-temperature late emulsification stage with glycerin/ethanol solubilizer.
6. Safety Profile
- Non-irritating to facial skin and eye mucosa at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- Excellent biocompatibility with human dermal fibroblasts and keratinocytes
- No cytotoxicity under routine leave-on cosmetic usage concentration
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, cool dry light-proof warehouse; short-term storage ≤4°C; avoid repeated opening & freeze-thaw cycles
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
