Product
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Acetyl Tetrapeptide-5
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：820959-17-9
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 5000000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Acetyl Tetrapeptide-5 (Eyeseryl) CAS 820959-17-9 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 820959-17-9
- INCI Name: Acetyl Tetrapeptide-5
- Trade Name: Eyeseryl
- Full Chemical Name: N-Acetyl-β-alanyl-L-histidyl-L-seryl-L-histidine
- Peptide Sequence: Ac-β-Ala-His-Ser-His-OH (Ac-βAla-HSH)
- IUPAC Name: (2S)-2-[[(2S)-2-[[(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
- Synonyms: Eye swelling peptide, ACE-1 inhibitory tetrapeptide
- Molecular Formula: C??H??N?O?
- Molecular Weight: 492.49 g/mol
- MDL No.: MFCD31689901
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white lyophilized crystalline powder |
| Odor | Odorless |
| Solubility | Freely soluble in purified water, PBS buffer (pH 6.0–7.5); slightly soluble in glycerin; insoluble in ethanol, oils, acetone |
| pH (0.1% aqueous solution) | 4.5 ~ 6.8 |
| Thermal Stability | Add below 45℃ during emulsification; avoid sustained heating above 60℃ |
| Stability | Stable under weak acid & neutral cosmetic systems; incompatible with strong alkali, high-concentration oxidants, long-term UV irradiation |
| Hygroscopicity | Moderately hygroscopic; vacuum sealed storage required |
3. Quality Specifications (Cosmetic Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Acetic Acid Residue | ≤0.10% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
| Heavy Metal | Limit |
|---|---|
| Lead (Pb) | ≤0.5 ppm |
| Arsenic (As) | ≤1.0 ppm |
| Cadmium (Cd) | ≤0.1 ppm |
| Mercury (Hg) | ≤0.1 ppm |
Microbial Limits
| Microbe Index | Standard |
|---|---|
| Total Aerobic Microbial Count | ≤500 CFU/g |
| Yeast & Mold | ≤50 CFU/g |
| E. coli, Salmonella, S. aureus | Negative per 25g |
4. Core Biological Mechanism & Efficacy
-
ACE-1 Inhibition to Eliminate Under-Eye Puffiness (Core Effect)
Suppresses Angiotensin-Converting Enzyme 1 activity, reduces vasoconstrictive peptide accumulation, improves microcirculation around eyes, relieves inflammatory edema and fluid retention under eyesMedChemExp....
-
Strengthen Periorbital Vessel Wall Elasticity
Upregulates collagen IV and laminin synthesis in dermal microvascular endothelium, reduces capillary fragility, prevents blood stagnation to fade dark circles caused by congestion.
-
Anti-Inflammatory & Anti-Oxidation for Delicate Eye Skin
Scavenges ROS free radicals, inhibits inflammatory cytokine release, alleviates redness, irritation and aging dullness of thin eye contour skin.
-
Reduce Fine Lines & Lift Loose Eyelid Skin
Stimulates fibroblast activity, boosts extracellular matrix secretion, improves sagging around eyes and smooths static fine lines at crow’s feet.
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Soothe Fatigued Eye Skin
Relieves swelling and dullness caused by staying up late, long screen time and environmental stress.
5. Application Fields & Recommended Dosage
5.1 Eye Contour Care (Main Application)
Anti-puffiness eye gel, dark circle repair cream, anti-wrinkle eye essence, fatigue-relief eye serum
- Recommended addition: 0.005% ~ 0.10% (w/w)
5.2 Anti-Aging Facial Skincare
Firming lifting serum, anti-edema lifting cream, sensitive soothing repair lotion
- Recommended addition: 0.001% ~ 0.05% (w/w)
Formula Operation Tips
Optimal formulation pH: 4.0–6.5; compatible with hyaluronic acid, caffeine, palmitoyl tetrapeptide-7, panthenol; add at low-temperature late stage of production.
6. Safety Profile
- Non-irritating to delicate eye mucosa and facial skin at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- Excellent biocompatibility with keratinocytes and vascular endothelial cells
- No cytotoxicity under routine cosmetic usage concentration
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, cool dry light-proof warehouse; short-term storage ≤4°C; avoid repeated opening & high temperature exposure
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
