Product
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Palmitoyl Tetrapeptide-7
- Brand：MAINTAIN
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：221227-05-0
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 500000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Palmitoyl Tetrapeptide-7 (Pal-GQPR / Rigin) CAS 221227-05-0 Full English Technical Datasheet
1. Basic Chemical Information
- CAS No.: 221227-05-0
- INCI Name: Palmitoyl Tetrapeptide-7
- Alias: Palmitoyl Tetrapeptide-3, Rigin, Pal-Gly-Gln-Pro-Arg, Core anti-inflammatory peptide of Matrixyl 3000
- Peptide Sequence: Palmitoyl-Glycyl-L-Glutaminyl-L-Prolyl-L-Arginine (Pal-GQPR)
- IUPAC Name: (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
- Molecular Formula: C??H??N?O?
- Molecular Weight: 694.91 g/mol
- MDL No.: MFCD11977710
- Core Feature: IgG-derived immunomodulatory lipopeptide; palmitoyl chain improves skin penetration & formulation compatibility
Pal-GQPR Chemical Structure
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white fine crystalline powder |
| Odor | Odorless |
| Solubility | Soluble in DMSO, ethanol, glycerin; dispersible in water with solubilizer; compatible with oil/water emulsions due to palmitoyl lipophilic tail |
| pH (0.1% aqueous dispersion) | 4.0 ~ 6.5 |
| Predicted Density | 1.26±0.1 g/cm3 |
| Thermal Stability | Add below 45℃ during emulsification; avoid sustained heating above 60℃ |
| Stability | Stable under weak acid & neutral formulas; incompatible with strong alkali, high-concentration oxidants & high UV exposure |
| Hygroscopicity | Slightly hygroscopic, airtight vacuum storage mandatory |
3. Quality Specifications (Cosmetic Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Related Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Palmitic Acid Residue | ≤0.10% | HPLC |
| Endotoxin | ＜50 EU/mg | LAL Test |
Heavy Metals
| Heavy Metal | Limit |
|---|---|
| Lead (Pb) | ≤0.5 ppm |
| Arsenic (As) | ≤1.0 ppm |
| Cadmium (Cd) | ≤0.1 ppm |
| Mercury (Hg) | ≤0.1 ppm |
Microbial Limits
| Microbe Index | Standard |
|---|---|
| Total Aerobic Microbial Count | ≤500 CFU/g |
| Yeast & Mold | ≤50 CFU/g |
| E. coli, Salmonella, S. aureus | Negative per 25g |
4. Core Biological Mechanism & Efficacy
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Inhibit Pro-Inflammatory Cytokine IL-6 (Anti-Inflammaging)
Significantly suppresses UV-induced IL-6 secretion in keratinocytes and fibroblasts; reduces chronic low-grade skin inflammation (inflamm-aging), the root cause of ECM degradation, sagging and dullness.
-
Boost Extracellular Matrix Synthesis
Stimulates type I collagen, fibronectin and hyaluronic acid production, thickens dermis, lifts loose skin, improves elasticity and reduces fine lines.
-
Reduce Puffiness & Dark Circles (Eye Contour Specialized)
Improves microcirculation around eyes, relieves inflammatory edema, fades under-eye puffiness and shadow caused by inflammatory congestion.
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Repair Photoaged & Sensitive Skin Barrier
Mitigates UV oxidative damage, alleviates redness and irritation from environmental stress, restores uniform smooth skin texture.
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Synergistic with Palmitoyl Tripeptide-1 (Matrixyl 3000 Compound)
Pal-GQPR (anti-inflammatory) + Pal-GHK (collagen booster) compound achieves dual anti-aging effects: anti-inflammation + collagen regeneration, widely used in mature skin care.
5. Application Fields & Recommended Dosage
5.1 Anti-Aging Facial Skincare
Anti-wrinkle serum, firming cream, anti-photoaging lotion, mature skin repair essence
- Recommended addition: 0.001% ~ 0.05% (w/w)
5.2 Eye Contour Care (Core Application)
Anti-puffiness eye gel, dark circle repair cream, anti-wrinkle eye essence
- Recommended addition: 0.005% ~ 0.08% (w/w)
5.3 Sensitive & Post-Sun Repair Products
Calming soothing lotion, UV repair gel, barrier repair cream
- Recommended addition: 0.001% ~ 0.03% (w/w)
Formula Operation Tips
Optimal pH range: 4.0–6.0; compatible with hyaluronic acid, vitamin C derivatives, copper peptide, panthenol; add at low temperature late stage of production.
6. Safety Profile
- Non-irritating to facial skin, eye mucosa at cosmetic standard dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- Excellent biocompatibility with keratinocytes and dermal fibroblasts
- No cytotoxicity under routine cosmetic usage concentration
7. Storage & Packaging
- Storage Condition: Hermetic nitrogen-filled aluminum foil vacuum bag; long-term storage at -20°C, cool dry light-proof warehouse; short-term storage ≤4°C; avoid repeated opening & high temperature exposure
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factories; 25kg double PE inner bag + paper drum for bulk orders
