Product
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Biotinoyl Tripeptide-1
- Brand：NO
- Model：1G,10G,1KG,5KG,25KG
- Purity：98%
- Cas：299157-54-3
- Createtime： 2026-07-02
- Updatetime： 2026-07-16
Product Details
| useage | FOR R&D RESEARCH USE |
| deliveryInfo | |
| appearance | white to off white powder |
| aliasen | |
| supplyCapacity | 500000KG/Year |
| harbor | SHENZHEN |
| minorder | 1G |
Biotinoyl Tripeptide-1 (Biotinyl-GHK / Bio-GHK) CAS 299157-54-3 Full English Technical Datasheet
Biotinoyl Tripeptide-1 Structure
1. Basic Chemical Information
- CAS No.: 299157-54-3
- Full Name: Biotinoyl Glycyl Histidyl Lysine
- Short Name: Biotinoyl Tripeptide-1, Bio-GHK, Biotin-GHK, Procapil core peptide
- Synonyms: Biotinyl-GHK, Widelash peptide, Hair growth tripeptide
- IUPAC Name: N-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)glycyl-L-histidyl-L-lysine
- Molecular Formula: C??H??N?O?S
- Molecular Weight: 566.68 g/mol
- MDL No.: MFCD34179872
2. Physical & Chemical Properties
| Test Item | Standard Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Odor | Slight faint biotin characteristic odor, nearly odorless |
| Solubility | Freely soluble in purified water, PBS buffer (pH 6.0–7.5); soluble in DMSO; slightly soluble in glycerin; insoluble in oils, ethanol, acetone |
| pH (0.1% aqueous solution) | 5.0 ~ 7.0 |
| Predicted Boiling Point | 1128.5±65.0 °C |
| Density | 1.321±0.06 g/cm3 |
| Stability | Stable under neutral & weak acidic aqueous systems; avoid strong alkali, high temperature (>60℃) and long-term UV exposure; resistant to common cosmetic preservatives |
| Hygroscopicity | Slightly hygroscopic, airtight storage required |
3. Quality Specifications (Cosmetic Grade)
| QC Item | Standard Limit | Test Method |
|---|---|---|
| Assay (HPLC, anhydrous basis) | ≥98.0%; Premium ≥99.0% | RP-HPLC UV 220 nm |
| Loss on Drying (KF) | ≤0.50% | Karl Fischer Titration |
| Residue on Ignition | ≤0.10% | Gravimetry |
| Single Unknown Impurity | ≤0.30% | HPLC |
| Total Related Impurities | ≤1.00% | HPLC |
| Free Biotin Residue | ≤0.10% | HPLC |
| Free GHK Tripeptide Residue | ≤0.10% | HPLC |
Heavy Metals
| Heavy Metal | Limit |
|---|---|
| Lead (Pb) | ≤0.5 ppm |
| Arsenic (As) | ≤1.0 ppm |
| Cadmium (Cd) | ≤0.1 ppm |
| Mercury (Hg) | ≤0.1 ppm |
Microbial Limits
| Microbe Index | Standard |
|---|---|
| Total Aerobic Microbial Count | ≤500 CFU/g |
| Yeast & Mold | ≤50 CFU/g |
| E. coli, Salmonella, S. aureus | Negative per 25g |
4. Core Biological Mechanism & Efficacy
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DHT Inhibition & Anti-Hair Loss
Suppresses 5α-reductase activity to reduce dihydrotestosterone (DHT) generation, the main factor causing follicle atrophy and androgenetic alopecia; blocks DHT damage to hair papilla cells.
-
Strengthen Hair Follicle Anchoring
Upregulates synthesis of Collagen IV and Laminin 5 in the dermal papilla and peri-follicle extracellular matrix, tightens hair root attachment, reduces hair shedding.
-
Prolong Anagen Growth Phase
Activates hair follicle vitality, increases the proportion of hair in active growth (anagen) phase, shortens telogen resting period, accelerates new hair regrowth.
-
Improve Scalp Microcirculation & Antioxidation
Promotes scalp blood circulation to deliver nutrients to follicles; scavenges ROS free radicals, relieves oxidative aging damage of scalp tissue.
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Eyelash & Eyebrow Thickening Effect
Stimulates proliferation of eyelash/eyebrow hair matrix cells, lengthens lash length, increases density and thickness, widely used in lash serums.
-
Skin Repair & Anti-Auxiliary Efficacy
Activates fibroblast proliferation, boosts collagen secretion, repairs damaged skin barrier, improves dull and loose skin.
5. Application Fields & Recommended Dosage
5.1 Hair Care Products (Main Application)
Anti-hair loss shampoo, anti-shedding hair conditioner, hair growth serum, scalp essence, hair tonic
- Recommended addition: 0.001% ~ 0.05% (w/w)
5.2 Eyelash & Eyebrow Cosmetics
Eyelash growth serum, eyebrow thickening gel, lash boosting essence
- Recommended addition: 0.005% ~ 0.08% (w/w)
5.3 Facial & Body Skincare
Anti-aging repair serum, sensitive skin barrier repair lotion, anti-oxidation brightening cream
- Recommended addition: 0.001% ~ 0.03% (w/w)
5.4 Biochemical Research Reagent
Cell culture additive for hair follicle tissue engineering, skin matrix metabolism research substrate
Formula Tip
Optimal formulation pH range: 4.0–6.5; compatible with panthenol, hyaluronic acid, copper peptide GHK-Cu, caffeine; avoid alkaline raw materials.
6. Safety Profile
- Non-irritating to scalp, facial skin and ocular mucosa at standard cosmetic dosage
- Non-sensitizing, non-phototoxic, no contact allergy risk
- Excellent biocompatibility with human keratinocytes and hair papilla cells
- No cytotoxicity recorded under routine usage concentration
7. Storage & Packaging
- Storage Condition: Hermetic aluminum foil vacuum sealed; long-term storage at -20°C, cool dry light-proof warehouse; short-term storage ≤4°C; avoid repeated opening and high temperature exposure
- Shelf Life: 36 months under intact original vacuum packaging
- Packaging: 1g/5kg aluminum vacuum foil bags for cosmetic factory formulation; 25kg double PE inner bag + paper drum for bulk orders
