1. Core Product Specifications

Product Name: Humanin (Human)
Alias: HN Peptide, Neuroprotective Peptide, Human Brain Protection Peptide
CAS No.: 330936-69-1
Amino Acid Sequence: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
Molecular Formula: C???H???N??O??S?
Molecular Weight: 2687.27 Da
Appearance: White or off-white lyophilized crystalline powder, odorless, non-caking, uniform color and high purity
Purity: ≥98.0% (HPLC tested, research grade)
Form: TFA salt (Trifluoroacetate salt)
Moisture Content: ≤2.0%
Heavy Metals: ≤10ppm
Endotoxin: ≤0.1EU/mg
Residue on Ignition: ≤0.1%
Solubility: Freely soluble in pure water and aqueous buffer solutions, clear and stable solution without precipitation
Transport Condition: Room temperature transportation
Storage Condition: Store dry powder at -20℃ sealed, dry and dark; aliquot and store prepared solution at -20℃, avoid repeated freeze-thaw cycles
Production Technology: Standard solid-phase peptide synthesis (SPPS), full-sequence assembly, multi-stage HPLC precision purification, low-temperature vacuum freeze-drying technology
Core Bioactivity: Neuroprotection, anti-apoptosis, anti-oxidation, anti-inflammatory, mitochondrial function regulation
Shelf Life: 24 months under standard -20℃ sealed and dry storage conditions
Usage Restriction: For scientific research use only, not for clinical or human therapeutic application

2. Professional Product Introduction

Humanin (CAS: 330936-69-1) is an endogenous 24-amino-acid neuroprotective polypeptide originally discovered in surviving brain cells of Alzheimer’s disease patients. As a key mitochondrial-derived peptide (MDP), it plays a vital regulatory role in neuronal survival, mitochondrial homeostasis, anti-apoptosis and anti-senescence. Humanin can effectively inhibit neuronal cell apoptosis induced by Aβ amyloid protein, oxidative stress and glucose deprivation, significantly reduce neuronal damage and cerebral nerve inflammation. It also improves mitochondrial energy metabolism, reduces reactive oxygen species (ROS) accumulation, and protects cognitive and neural functions. Widely recognized as a core protective factor for neurodegenerative diseases, it is extensively applied in Alzheimer’s disease, Parkinson’s disease, cerebral ischemia injury, anti-aging neuroscience, mitochondrial mechanism research and neuroprotective drug screening.

3. Product Description

This product is high-purity research-grade human-derived Humanin lyophilized peptide powder, synthesized by mature and reliable solid-phase peptide synthesis technology with full-length accurate sequence assembly. After multi-stage high-precision HPLC purification, truncated fragments, mis-sequence impurities, synthetic residues and isomers are thoroughly removed, ensuring stable purity above 98.0% and excellent batch consistency. Supplied in conventional TFA salt form, the product features excellent water solubility and biological compatibility, adapting to various cell culture systems, biochemical buffer environments and in-vivo animal experiments. Strict control of endotoxin and heavy metal residues ensures ultra-low cytotoxicity and high experimental safety. With stable physicochemical properties and powerful biological activity, this standardized Humanin peptide provides highly repeatable and reliable experimental data, making it a premium tool material for neuroscience research, mitochondrial functional verification, neuroprotection mechanism exploration and anti-neurodegenerative drug development.