1. Core Product Specifications

Product Name: Eloralintide
CAS No.: 2883634-40-8
Sequence: {γGlu}-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gly-{Orn}-Leu-Ala-Glu-{(α-Me-Phe)}-Leu-Val-Arg-Ser-Ser-Asn-{(N-Me-Asn)}-Phe-Gly-Pro-{Lys(γGlu-γGlu-C20 diacid)}-Leu-Pro-Pro-Thr-Glu-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Cys2-Cys7 methylene-bridged cyclic structure)
Molecular Formula: C???H???N??O??S?
Molecular Weight: 4526.2 Da
Elemental Composition: C:53.34%, H:7.10%, N:15.16%, S:1.42%
Appearance: White to off-white lyophilized polypeptide powder, loose texture, non-caking, free of visible impurities
Purity: ≥98.0% (HPLC tested, pharmaceutical research grade)
Moisture Content: ≤2.0%
Heavy Metals: ≤10ppm
Endotoxin: ≤0.1EU/mg
Solubility: Freely soluble in pure water, weak acid buffers and aqueous systems, forming clear and stable solutions
Transport Condition: Room temperature transportation
Storage Condition: Long-term storage at 2–8℃ in sealed, dry and dark environment; prepare and aliquot solutions for frozen storage at -20℃, avoid repeated freeze-thaw cycles
Production Technology: Long-chain solid-phase peptide synthesis, site-specific methylation modification, special amino acid embedding, intramolecular cyclic bridging modification, multi-stage HPLC precision purification, low-temperature vacuum freeze-drying technology
Product Attribute: Novel long-chain modified functional polypeptide, pharmaceutical-grade reference standard, exclusive raw material for biomedical research
Customization: Synthesis on demand
Shelf Life: 24 months under standard low-temperature sealed storage conditions
Usage Restriction: For laboratory research and analytical development only, not for human clinical applications

2. Professional Product Introduction

Eloralintide (CAS: 2883634-40-8) is a highly complexnovel long-chain modified functional polypeptide classified as a high-end biomedical-grade active raw material. Its molecular structure contains multiple unique modifications, including α-methylphenylalanine, N-methylasparagine, ornithine, and long-chain γ-glutamic diacid substitution, together with a stable Cys2-Cys7 methylene cyclic bridge. Different from conventional short peptides, Eloralintide features a sophisticated molecular configuration and extremely high biological specificity. As a cutting-edge targeted functional peptide, it is widely applied in new drug research and development, analytical method development, pharmaceutical quality control, ANDA submission, forced degradation testing, and pharmacopoeia calibration. Serving as a professional pharmaceutical reference standard, it supports accurate drug identification, content determination, methodological verification, and quality system establishment, making it a benchmark material for innovative polypeptide drug development and regulatory compliance research.

3. Product Description

This product is high-purity pharmaceutical-grade Eloralintide lyophilized powder, manufactured via high-precision long-chain solid-phase peptide synthesis. It accurately completes site-specific embedding of special amino acids, targeted methylation, and intramolecular cyclic bridge construction, ensuring full-sequence accuracy without mismatched fragments. Through multi-stage high-precision preparative HPLC purification, truncated peptides, mis-sequence impurities, synthetic by-products and isomers are thoroughly removed, delivering stable purity above 98.0% with excellent sequence integrity and batch-to-batch consistency. Multiple customized structural modifications provide outstanding molecular stability and specific biological recognition abilities, featuring strong acid-base resistance and anti-degradation performance. It fully adapts to rigorous pharmaceutical research scenarios including analytical validation, stability investigation, and degradation mechanism analysis. All key indicators such as endotoxin, heavy metals and organic residues are strictly controlled to meet USP/EP pharmacopoeia standards. It is a rare high-end reference standard ideal for advanced pharmaceutical R&D, drug registration, quality traceability and forced degradation studies.

4. Core Product Advantages

1. Unique Complex Modified Structure with High Scarcity
Integrating multiple special amino acid substitutions, methylation modifications and cyclic bridging structures, Eloralintide possesses an exclusive molecular configuration that cannot be replaced by ordinary commercial peptides. It serves as an indispensable core material for cutting-edge polypeptide drug innovation and pharmaceutical analytical research with high scientific research value.

2. Pharmacopoeia-Grade High Purity for Drug Registration
With purity ≥98% and strict impurity control, this product fully complies with USP/EP pharmacopoeia criteria. It can be directly used for ANDA submission, DMF filing, drug identification, content detection and methodological verification, perfectly meeting high-standard compliance R&D requirements of pharmaceutical enterprises and research institutions.

3. Ultra-Stable Molecular Structure with Wide Experimental Adaptability
The dual-stability system composed of intramolecular cyclic bridge and multi-site methylation effectively resists hydrolysis, metabolic degradation, temperature and pH fluctuation. It performs stably in forced degradation experiments, long-term stability tests and various pharmaceutical studies, ensuring excellent experimental repeatability and reliable data output.

4. Professional Pharmaceutical-Grade Targeted Application
Specially customized for polypeptide drug development, it precisely covers drug qualitative and quantitative analysis, quality control, degradation mechanism exploration and pharmaceutical method establishment. It is a core standard material for pharmaceutical R&D institutions, drug inspection agencies and academic research projects.

5. Customizable Synthesis with Controllable Batch Quality
Adopting advanced customized synthesis technology, it supports mass production according to research demands with full traceable production records and complete data documents. Full compliance certification reports are available, suitable for long-term scientific research projects and large-scale pharmaceutical development.