1. Core Product Specifications

Product Name: c(RGDfK)
Full Name: Cyclo(Arg-Gly-Asp-D-Phe-Lys)
Abbreviation: Cyclic RGDfK Peptide
CAS No.: 161552-03-0
Amino Acid Sequence: cyclo(-Arg-Gly-Asp-D-Phe-Lys-) (R-G-D-f-K)
Molecular Formula: C??H??N?O?
Molecular Weight: 603.67 Da
Isoelectric Point (pI): Approximately 9.7
Appearance: White lyophilized crystalline powder, odorless, non-caking, uniform color with ultra-low impurities
Purity: ≥95% / ≥98% (HPLC optional, research grade)
Form: TFA salt (Trifluoroacetate salt, common commercial form)
Moisture Content: ≤2.0%
Heavy Metals: ≤10ppm
Endotoxin: ≤0.1EU/mg
Residue on Ignition: ≤0.1%
Solubility: Freely soluble in pure water and aqueous buffer solutions; clear and stable aqueous solution
Storage Conditions: Store dry powder at -20℃ sealed, dry and dark; aliquot and store solution at -20℃, avoid repeated freeze-thaw cycles
Production Technology: Solid Phase Peptide Synthesis (SPPS), head-to-tail cyclization, D-amino acid chiral modification, multi-stage HPLC precision purification, low-temperature vacuum freeze-drying
Biological Activity: Ultra-high affinity integrin αvβ3/αvβ5 competitive inhibitor, IC50 ≈ 0.94 nM
Shelf Life: 24 months for dry powder under standard sealed -20℃ storage
Usage Restriction: For scientific research only, not for clinical human treatment

2. Professional Product Introduction

c(RGDfK) (CAS: 161552-03-0) is a highly stable artificial synthetic head-to-tail cyclic pentapeptide, composed of Arg-Gly-Asp-D-Phe-Lys amino acid sequence. The unique introduction of D-type phenylalanine (D-Phe) effectively optimizes the molecular chiral configuration, significantly improves anti-peptidase degradation ability and receptor binding affinity, showing far higher stability and targeting performance than linear RGD peptides and ordinary cyclic RGD variants. c(RGDfK) acts as an ultra-high affinity ligand and competitive inhibitor for integrin αvβ3 and αvβ5, which are highly overexpressed in tumor neovascular endothelial cells and various malignant tumor cells. With an extremely low IC50 of 0.94 nM, it is recognized as the gold-standard targeted cyclic peptide in tumor imaging, targeted drug delivery and integrin mechanism research. It is widely applied in nuclear medicine imaging probe coupling, nano-drug modification, tumor targeted enrichment and cell migration adhesion experiments.