1. Core Product Specifications

Product Name: Cilengitide
Full Chemical Name: Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
CAS No.: 188968-51-6
Molecular Formula: C??H??N?O?
Molecular Weight: 588.66
Appearance: White or off-white crystalline lyophilized powder, odorless, free of impurities and caking
Purity: ≥99.0% (HPLC tested)
Melting Point: N/A (Peptide powder)
Density: 1.4±0.1 g/cm3
Moisture Content: ≤2.0%
Heavy Metals: ≤10ppm
Endotoxin: ≤1 EU/mg
Solubility: Freely soluble in water and aqueous buffer solutions, slightly soluble in methanol, practically insoluble in non-polar organic solvents
Storage Condition: Powder stored at 2-8℃ sealed and dry; solution stored at -20℃, avoid repeated freeze-thaw cycles
Production Technology: Solid-phase peptide synthesis (SPPS), cyclization reaction, multi-stage HPLC purification, low-temperature freeze-drying
Biological Activity: Highly selective integrin αvβ3 / αvβ5 inhibitor
Shelf Life: 24 months for powder; 6 months for prepared solution under standard storage

2. Professional Product Introduction

Cilengitide (CAS: 188968-51-6) is a cyclic RGD pentapeptide with N-methyl modification, recognized as a high-efficiency and highly selective integrin receptor inhibitor in biomedical research. It specifically targets and competitively inhibits the binding of integrin αvβ3 and αvβ5 with extracellular matrix ligands, with extremely low IC50 values of 4 nM and 79 nM respectively, showing superior targeted inhibitory activity. Integrin αvβ3 and αvβ5 are key regulatory proteins involved in tumor angiogenesis, endothelial cell migration, tumor invasion and metastasis, and inflammatory vascular remodeling. As a classic targeted polypeptide tool compound, Cilengitide effectively blocks abnormal vascular proliferation and tumor microenvironment remodeling, stably regulates cell adhesion and migration signaling pathways. Widely applied in tumor pharmacology research, angiogenesis mechanism study, anti-tumor drug screening, inflammatory injury model establishment and targeted biomedical mechanism verification, it is a core high-purity polypeptide reagent for cell biology and oncology research.